Results 1 to 10 of about 4,854 (136)
The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling. [PDF]
Front Physiol, 2021 Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET.
Lai J, Chen C.
europepmc +5 more sources
CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators [PDF]
Molecules, 2022 Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed ...
Dao Wen Wang, Zuowen He, Wang Dao Wen
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Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study [PDF]
EBioMedicine, 2022 Summary: Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and part
Amanda Fretts, Rozenn Lemaitre
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Inside epoxyeicosatrienoic acids and cardiovascular disease. [PDF]
Front Pharmacol, 2014 Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis.
Tacconelli S, Patrignani P.
europepmc +5 more sources
Anti-inflammatory effects of epoxyeicosatrienoic acids. [PDF]
Int J Vasc Med, 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their ...
Thomson SJ, Askari A, Bishop-Bailey D.
europepmc +6 more sources
The role of epoxyeicosatrienoic acids in the cardiovascular system [PDF]
British Journal of Clinical Pharmacology, 2015 There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors.
Joseph Cheriyan, Kaisa Mäki-Petäjä
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Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance This study furthers our understanding of epoxyeicosatrienoic acid metabolism by cyclooxygenase (COX) enzymes as a physiologically relevant metabolic pathway, producing signaling molecules that are angiogenic. It explains, in part, why inhibiting the soluble epoxide hydrolase (sEH) in some systems is angiogenic whereas ...
Christophe Morisseau +2 more
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Epoxyeicosatrienoic acids and glucose homeostasis in mice and men [PDF]
Prostaglandins and Other Lipid Mediators, 2016 Epoxyeicosatrienoic acids (EETs) are formed from arachidonic acid by the action of P450 epoxygenases (CYP2C and CYP2J). Effects of EETs are limited by hydrolysis by soluble epoxide hydrolase to less active dihydroxyeicosatrienoic acids. Studies in rodent models provide compelling evidence that epoxyeicosatrienoic acids exert favorable effects on ...
Nancy Brown, Luther Jm
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Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). [PDF]
PLoS One, 2013 Inflammation is a key element in many cardiovascular diseases. Both estrogen loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory molecules synthesized by various cytochrome P450 (Cyp)
Lee AR +4 more
europepmc +7 more sources
The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids [PDF]
Frontiers in PharmacologyArachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Wang Dao Wen
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