Results 41 to 50 of about 4,873 (155)

Renal epoxyeicosatrienoic acid synthesis during pregnancy [PDF]

American Journal of Physiology-Renal Physiology, 2005
Epoxyeicosatrienoic acids (EETs), which belong to cytochrome P-450 (CYP)-derived eicosanoids, have been implicated to vasodilate renal arterioles, inhibit sodium transport in the nephron, and regulate blood pressure in several animal models. Because pregnancy is associated with changes of blood pressure, the aim of this study was to examine whether ...
Yiqiang, Zhou, Hsin-Hsin, Chang, Juan, Du, Cong-Yi, Wang, Zheng, Dong, Mong-Heng, Wang   +5 more
openaire   +2 more sources

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity

Journal of Lipid Research, 2014
Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a potential therapeutic target for cardiometabolic disease, the functional ...
Weibin Zha, Matthew L. Edin, Kimberly C. Vendrov, Robert N. Schuck, Fred B. Lih, Jawahar Lal Jat, J. Alyce Bradbury, Laura M. DeGraff, Kunjie Hua, Kenneth B. Tomer, John R. Falck, Darryl C. Zeldin, Craig R. Lee   +12 more
doaj   +1 more source

Determination of Lipoxygenase, CYP450, and Non-Enzymatic Metabolites of Arachidonic Acid in Essential Hypertension and Type 2 Diabetes

Metabolites, 2022
Type 2 diabetes (T2D) and hypertension (HTN) are common risk factors of cardiovascular diseases (CVD) characterized by chronic low-grade systemic inflammation and impaired endothelial function.
Guillaume Feugray, Tony Pereira, Michèle Iacob, Lucile Moreau-Grangé, Gaëtan Prévost, Valéry Brunel, Robinson Joannidès, Jérémy Bellien, Thomas Duflot   +8 more
doaj   +1 more source

5,6-, 8,9-, 11,12- and 14,15-Epoxyeicosatrienoic Acids (EETs) Induce Peripheral Receptor-Dependent Antinociception in PGE2-Induced Hyperalgesia in Mice

Pharmacology and Clinical Pharmacy Research
Epoxyeicosatrienoic acids (EETs) are cytochrome P450-epoxygenase-derived metabolites of arachidonic acid that act as endogenous signaling molecules in multiple biological systems, including their controversial effects on pain, including reports of the ...
Flavia C.S Fonseca, Igor D.G Duarte
doaj   +1 more source

Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibition.

PLoS ONE, 2014
Inner medulla collecting duct (IMCD) cells are the key part for urinary concentration. Hypotonic stress may trigger apoptosis of IMCD cells and induce renal injury.
Luyun Wang, Yang Liu, Huamin Wang, Xun Liu, Jie Chen, Mong-Heng Wang, Jingfeng Wang, Hui Huang   +7 more
doaj   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Eicosanoid Profile of Influenza A Virus Infected Pigs

Metabolites, 2019
Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection ...
Daniel Schultz, Karen Methling, KoInfekt Study Group, Michael Rothe, Michael Lalk   +4 more
doaj   +1 more source

Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats

Frontiers in Physiology, 2021
Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function.
Agnieszka Walkowska, Luděk Červenka, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski, Elżbieta Kompanowska-Jezierska   +6 more
doaj   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

Integrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu, Xiang‐Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong   +5 more
wiley   +1 more source

Circadian Variation in Vasoconstriction and Vasodilation Mediators and Baroreflex Sensitivity in Hypertensive Rats

Journal of Circadian Rhythms, 2019
The purpose of this study was to evaluate the relationship between the circadian profile of the vasorelaxing substances calcitonin gene-related peptide (CGRP) and epoxyeicosatrienoic acids (EETs) and the vasconstrictive agent endothelin-1 (ET1) and the ...
Tamar Kezeli, Nikoloz Gongadze, Galina Sukoyan, Marina Shikhashvili, Zaza Chapichadze, Maia Okujava, Nino Dolidze   +6 more
doaj   +1 more source