The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification [PDF]
International Journal of Molecular Sciences, 2020 Bellien Jeremy +2 more
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Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. [PDF]
PLoS ONE, 2015 Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR).
Giuseppina Mattace Raso +11 more
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Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans [PDF]
Prostaglandins and Other Lipid Mediators, 2014 Nancy Brown, Luther Jm, Chang Yu
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Epoxyeicosatrienoic Acid Analogs and Vascular Function [PDF]
Current Medicinal Chemistry, 2010 Arachidonic acid metabolites, eicosanoids, are key contributors to vascular function and improper eicosanoid regulation contributes to the progression of cardiovascular diseases. Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by epoxygenase enzymes to four regioisomers, 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. These EETs have
V, Sudhahar, S, Shaw, J D, Imig
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Vascular Pharmacology of Epoxyeicosatrienoic Acids [PDF]
, 2010 Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in responses to various stimuli such as the agonists acetylcholine (ACH) or bradykinin or by shear stress which activates phospholipase A(2) to release arachidonic acid.
Sandra L, Pfister +2 more
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Bulletin of the National Research Centre, 2018 Background Insulin-producing cells differentiated from human mesenchymal stem cells demonstrate limited glucose-stimulated insulin secretion. Cytochrome P450 2J2 and its product epoxyeicosatrienoic acids regulate β-cell function in the human pancreas ...
Loaa A. Tag Eldeen +2 more
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Orally Active Epoxyeicosatrienoic Acid Analogs [PDF]
Journal of Cardiovascular Pharmacology, 2017 Abstract: Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release.
William B, Campbell +3 more
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Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine
Frontiers in Veterinary Science, 2020 The veterinary pharmacopeia available to treat pain and inflammation is limited in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs being tested ...
Diyala S. Shihadih +11 more
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Lipid regulation of BK channel function
Frontiers in Physiology, 2014 This mini-review focuses on lipid modulation of BK (MaxiK, BKCa) current by a direct interaction between lipid and the BK subunits and/or their immediate lipid environment.
Alex M. Dopico, Anna N. Bukiya
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Epoxyeicosatrienoic acids and endothelium-dependent responses [PDF]
Pflügers Archiv - European Journal of Physiology, 2010 Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological actions that are involved in the regulation of vascular ...
William B, Campbell, Ingrid, Fleming
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