Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study. [PDF]
EBioMedicine, 2021 Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited.
Lemaitre RN +14 more
europepmc +2 more sources
Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling. [PDF]
Biomedicines, 2020 Elevated cis-epoxyeicosatrienoic acids (EETs) are known to be cardioprotective during ischemia-reperfusion injury in cardiomyocyte-specific overexpressing cytochrome P450 2J2 (CYP2J2) transgenic (Tr) mice.
Aliwarga T +8 more
europepmc +2 more sources
Epoxyeicosatrienoic acids, hypertension, and kidney injury. [PDF]
Hypertension, 2015 Kidney disease afflicts 33 million in the United States, and chronic kidney disease (CKD) accounts for >$60 billion in Medicare costs.1,2 Hypertension afflicts 75 million in the United States, and significant portions of those patients develop CKD and progress to end-stage renal disease.1–5 Interestingly, resistant hypertension which is defined as ...
Imig JD.
europepmc +4 more sources
CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina. [PDF]
Int J Cardiol Heart Vasc, 2017 Background: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease.
Akasaka T +15 more
europepmc +2 more sources
Epoxyeicosatrienoic acids and cardioprotection: the road to translation. [PDF]
J Mol Cell Cardiol, 2014 AbstractCardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this ...
Oni-Orisan A +3 more
europepmc +6 more sources
Overexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acids. [PDF]
PLoS One, 2015 The cytochrome P450 epoxygenase-dependent arachidonic acid metabolites, epoxyeicosatrienoic acids (EETs), are potent survival factors and mitogens for renal epithelial cells, but the molecular identity in the cells that initiates the mitogenic signaling ...
Ma SK +5 more
europepmc +2 more sources
Renal And Cardiovascular Actions Of 20-Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids [PDF]
Clinical and Experimental Pharmacology and Physiology, 2000 SUMMARY1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the kidney and the peripheral vasculature.2. The present short review summarizes the renal and cardiovascular actions of these important mediators.3. Epoxyeicosatrienoic acids are
, M Alonso-Galicia, D R Harder
exaly +3 more sources
CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/13. [PDF]
J Lipid Res, 2017 The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system.
He Z +7 more
europepmc +2 more sources
Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function. [PDF]
Adv Pharmacol, 2016 Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid metabolites that can impact endothelial cell function and vascular homeostasis. The objective of this review is to focus on the physiology and pharmacology of endothelial CYP metabolites.
Imig JD.
europepmc +4 more sources
Maternal and fetal epoxyeicosatrienoic acids in normotensive and preeclamptic pregnancies. [PDF]
Am J Hypertens, 2013 Epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) are cytochrome P450 metabolites of arachidonic acid posited to act in the circulatory adaptation to pregnancy and the development of preeclampsia. Red blood cells (RBCs) may function as major contributors of cis- and trans-EETs.We performed paired analyses of EETs ...
Jiang H +7 more
europepmc +5 more sources