Results 31 to 40 of about 4,873 (155)

Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

Journal of Lipid Research, 1987
Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their ...
J R Falck, V J Schueler, H R Jacobson, A K Siddhanta, B Pramanik, J Capdevila   +5 more
doaj   +1 more source

14,15-Epoxyeicosatrienoic Acid Protect Against Glucose Deprivation and Reperfusion-Induced Cerebral Microvascular Endothelial Cells Injury by Modulating Mitochondrial Autophagy via SIRT1/FOXO3a Signaling Pathway and TSPO Protein

Frontiers in Cellular Neuroscience, 2022
Neurovascular system plays a vital role in controlling the blood flow into brain parenchymal tissues. Additionally, it also facilitates the metabolism in neuronal biological activities.
Youyang Qu, Jinlu Cao, Di Wang, Shu Wang, Yujie Li, Yulan Zhu   +5 more
doaj   +1 more source

Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats

Frontiers in Pharmacology, 2022
Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial effects,
Iwona Baranowska, Iwona Baranowska, Olga Gawrys, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Luděk Červenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elżbieta Kompanowska-Jezierska   +10 more
doaj   +1 more source

Epoxyeicosatrienoic Acids and/or Their Metabolites Promote Hypoxic Response of Cells

Journal of Pharmacological Sciences, 2008
Epoxyeicosatrienoic acids (EETs), including 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET, are produced by cytochrome P450 (P450) such as CYP2C8 and 2C9; and they are hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide hydrolase.
Sachiko Suzuki, Ami Oguro, Mayuko Osada-Oka, Yoshihiko Funae, Susumu Imaoka   +4 more
doaj   +1 more source

Epoxyeicosatrienoic acids and soluble epoxide hydrolase in physiology and diseases of the central nervous system

Chinese Journal of Physiology, 2022
Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 epoxygenases from arachidonic acid. The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that
Yi-Min Kuo, Yi-Hsuan Lee
doaj   +1 more source

Endothelium-Derived Epoxyeicosatrienoic Acids and Vascular Function [PDF]

Hypertension, 2006
Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor ...
Ingrid, Fleming, Rudi, Busse
openaire   +2 more sources

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer

Frontiers in Pharmacology, 2020
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
doaj   +1 more source

Conversion of epoxyeicosatrienoic acids (EETs) to chain-shortened epoxy fatty acids by human skin fibroblasts

Journal of Lipid Research, 2000
Epoxyeicosatrienoic acids (EETs), the eicosanoid biomediators synthesized from arachidonic acid by cytochrome P450 epoxygenases, are inactivated in many tissues by conversion to dihydroxyeicosatrienoic acids (DHETs).
Xiang Fang, Terry L. Kaduce, Mike VanRollins, Neal L. Weintraub, Arthur A. Spector   +4 more
doaj   +1 more source

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury

Journal of Lipid Research, 2012
Epoxyeicosatrienoic acids (EET), the primary arachidonic acid metabolites of cytochrome P450 2J (CYP2J) epoxygenases, possess potent vasodilatory, anti-inflammatory, antiapoptotic, and mitogenic effects.
Gang Zhao, Jianing Wang, Xizhen Xu, Yanyan Jing, Ling Tu, Xuguang Li, Chen Chen, Katherine Cianflone, Peihua Wang, Ryan T. Dackor, Darryl C. Zeldin, Dao Wen Wang   +11 more
doaj   +1 more source

Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors

Frontiers in Pharmacology, 2020
Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune ...
Eric A. Evangelista, Christi W. Cho, Theresa Aliwarga, Rheem A. Totah   +3 more
doaj   +1 more source