Results 61 to 70 of about 4,873 (155)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, Volume 16, Issue 7, Page 1328-1339, July 2026.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner

Ecotoxicology and Environmental Safety, 2023
Aflatoxin B1 (AFB1) contamination in food and feed leads to severe global health problems. Acting as the frontier immunological barrier, the intestinal mucosa is constantly challenged by exposure to foodborne toxins such as AFB1 via contaminated diets ...
Weicang Wang, Yuxin Wang, Jun Yang, Karen M. Wagner, Sung Hee Hwang, Jeff Cheng, Nalin Singh, Patricia Edwards, Christophe Morisseau, Guodong Zhang, Dipak Panigrahy, Bruce D. Hammock   +11 more
doaj   +1 more source

Polygonatum cyrtonema Polysaccharides‐Derived Metabolic Meta Alleviates ALD via a Gut–Liver Axis–Mediated, Bifidobacterium pseudolongum–Driven Suppression of the AA Metabolism–MAPK Signaling Network

Food Frontiers, Volume 7, Issue 4, July 2026.
This study demonstrates that the hepatoprotective effect of Polygonatum cyrtonema polysaccharide (PCP) is mediated by its gut microbiota‐derived metabolome, which enriches Bifidobacterium pseudolongum, suppresses the gut–liver axis of AA metabolism, and inhibits hepatic MAPK signaling. ABSTRACT Polygonatum cyrtonema, a traditional Chinese medicinal and
Xingcai Gao, Qing Zhou, Baoting Liu, Jun Li, Jianhua Xie, Yi Chen, Chenxu Gong, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population

Neuropsychiatric Disease and Treatment, 2021
Birsen Can Demirdöğen,1 Yağmur Miçooğulları,2 Aysun Türkanoğlu Özçelik,3 Orhan Adalı4 1Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey; 2Institute of Natural and Applied ...
Can Demirdöğen B, Miçooğulları Y, Türkanoğlu Özçelik A, Adalı O   +3 more
doaj  

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2

Protein Science, Volume 35, Issue 7, July 2026.
Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das, Henry M. Mastrion, Harrison B. Vassar, Aditi Das   +3 more
wiley   +1 more source

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi‐Omics and Experimental Study

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai, Siyu Han, Xiaoping Hu, Jiakuo Gu, Dongmei Liu, Jiale Wu, Juyan Zheng, Shiqin Hong, Yiwen Zhang   +8 more
wiley   +1 more source

The Hunt for the Putative Epoxyeicosatrienoic Acid Receptor

ACS Chemical Biology
Epoxyeicosatrienoic acids, or EETs, are signaling molecules formed by the metabolism of arachidonic acid by cytochrome P450 enzymes. They are well-known for their anti-inflammatory effects, their ability to lower blood pressure, and benefits to cardiovascular outcomes.
William R. Arnold, Sona Jain, Vidya Sinha, Aditi Das   +3 more
openaire   +2 more sources