Results 81 to 90 of about 4,873 (155)

A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract Anti‐amyloid therapies for Alzheimer's disease (AD) modestly slow cognitive decline but carry significant risk of amyloid‐related imaging abnormalities (ARIAs), brain swelling, and hemorrhage, particularly in apolipoprotein E ε4 carriers. Cerebral amyloid angiopathy (CAA) and vascular inflammation drive this vulnerability, highlighting the ...
Ambreen Kanwal, Bilal E. Kerman, Shaowei Wang, Kevin Camey, Boyang Li, Lisi Flores‐Aguilar, Nada Ali, Laura Beth McIntire, Chang April Shu, Stan G. Louie, Elizabeth Head, Zoe Arvanitakis, Hussein N. Yassine   +12 more
wiley   +1 more source

Association of the sEH gene promoter polymorphisms and haplotypes with preeclampsia [PDF]

Journal of Medical Biochemistry, 2020
Background: The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory, and organ protective properties and their circulation levels are related to hypertension, diabetes mellitus, cardiovascular diseases, and preeclampsia.
Sarı İsmail, Ökten Hatice, Aktan Çağdaş, Cihan Esra   +3 more
doaj  

Regulation of P450-derived epoxy fatty acids in cardiovascular diseases

Redox Biochemistry and Chemistry
The cytochrome P450 (P450 or CYP) superfamily, while extensively recognized for xenobiotic metabolism, is also critically involved in the biosynthesis of lipid mediators from polyunsaturated fatty acids (PUFAs).
Matthew L. Edin, Joan P. Graves, Darryl C. Zeldin   +2 more
doaj   +1 more source

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study

Journal of Lipid Research, 2016
Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent cardiovascular protective effects in preclinical models, and promoting the effects of EETs has emerged as a potential therapeutic strategy for coronary artery disease (CAD ...
Akinyemi Oni-Orisan, Matthew L. Edin, John Andrew Lee, Michael A. Wells, Erin S. Christensen, Kimberly C. Vendrov, Fred B. Lih, Kenneth B. Tomer, Xue Bai, Joan M. Taylor, George A. Stouffer, Darryl C. Zeldin, Craig R. Lee   +12 more
doaj   +1 more source

Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function [PDF]

Prostaglandins & Other Lipid Mediators, 2013
The development of pharmacological, genetic, and biochemical tools have allowed for detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of arachidonic acid to renal microvascular function. Renal microvessels can generate CYP hydroxylase metabolites including 20-hydroxyeicosatetraenoic acid (20-HETE) and CYP epoxygenase ...
openaire   +2 more sources

Mechanism Underlying Endothelium-Dependent Relaxation by 2-Methylthio-ADP in Monkey Cerebral Artery

Journal of Pharmacological Sciences, 2010
We recently reported endothelium-dependent relaxation caused by nucleotides in the non-human primate cerebral artery. Here, we investigated the endothelium-dependent, nitric oxide- and prostanoid-independent relaxation induced by 2-methylthio-ADP ...
Ayman Geddawy, Takashi Shimosato, Masashi Tawa, Takeshi Imamura, Tomio Okamura   +4 more
doaj   +1 more source

Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation. [PDF]

Int J Mol Sci, 2022
Aliwarga T, Dinh JC, Heyward S, Prasad B, Gharib SA, Lemaitre RN, Sotoodehnia N, Totah RA.   +7 more
europepmc   +1 more source

Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies. [PDF]

Int J Mol Sci, 2021
Guan XX, Rao DN, Liu YZ, Zhou Y, Yang HH.   +4 more
europepmc   +1 more source

Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. [PDF]

Proc Natl Acad Sci U S A, 2022
Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC.   +7 more
europepmc   +1 more source

Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids. [PDF]

Hypertension, 2021
Luther JM, Wei DS, Ghoshal K, Peng D, Adler GK, Turcu AF, Nian H, Yu C, Solorzano CC, Pozzi A, Brown NJ.   +10 more
europepmc   +1 more source