Results 171 to 180 of about 2,734,900 (203)

Collisionally induced dissociation of epoxyeicosatrienoic acids and epoxyeicosatrienoic acid-phospholipid molecular species

Analytical Biochemistry, 1991
Four isomers of epoxyeicosatrienoic acid (EET) can be formed by cytochrome P-450 oxidation of arachidonic acid: 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid. The collision-induced dissociation of the [M-H]- anion at m/z 319 from each of these isomers, using negative-ion fast atom bombardment ionization and a triple quadrupole mass ...
K, Bernstrom, K, Kayganich, R C, Murphy
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Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy

Trends in Pharmacological Sciences, 2016
Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition. sEH is the enzyme that converts EET to its less potent metabolite; therefore, EET is upregulated by its ...
Nader G Abraham, John A McClung, Joseph Schragenheim   +2 more
exaly   +3 more sources

Action of epoxyeicosatrienoic acids on cellular function

American Journal of Physiology-Cell Physiology, 2007
Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by cytochrome P-450 epoxygenases. They activate smooth muscle large-conductance Ca2+-activated K+ channels, producing hyperpolarization and vasorelaxation.
Arthur A, Spector, Andrew W, Norris
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Potentiation of Endothelium-Dependent Relaxation by Epoxyeicosatrienoic Acids

Circulation Research, 1997
AbstractEpoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) are also avidly taken up by endothelial cells and incorporated into phospholipids that participate in signal transduction.
Neal L Weintraub, Arthur A Spector, Mike Vanrollins   +2 more
exaly   +3 more sources

Influence of epoxyeicosatrienoic acids on uterine function

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1997
In spite of the large quantities of epoxyeicosatrienoic acids (EEts) released by reproductive tissues, their function has not yet been determined. In order to analyze the influence of epoxygenase products on isolated uterine function, Clotrimazole, a cytochrome P450 inhibitor was used. The drug decreased isolated rat uterine isometric developed tension
E, Gonzalez, A, Jawerbaum, V, Novaro, M A, Gimeno   +3 more
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Erythrocyte-derived epoxyeicosatrienoic acids

Prostaglandins & Other Lipid Mediators, 2007
Red blood cells (RBCs) are reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs) that can be released. The sources of EET release from RBCs include direct synthesis from arachidonic acid, peroxidation of phospholipids and EETs esterified into cellular phospholipids. The release of EETs from RBCs can be through cytosolic phospholipase A2 (PLA2),
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Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension

Current Opinion in Nephrology and Hypertension, 2004
Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis, Bernardo, Lopez, Richard J, Roman   +2 more
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Renal and Cardiovascular Actions of 20-Hydroxyeicosatetraenoic Acid and Epoxyeicosatrienoic Acids [PDF]

Clinical and Experimental Pharmacology and Physiology, 2000
SUMMARY1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the kidney and the peripheral vasculature.2. The present short review summarizes the renal and cardiovascular actions of these important mediators.3. Epoxyeicosatrienoic acids are
Chengwen Sun, Richard J Roman, Magdalena Alonso-Galicia   +2 more
exaly   +3 more sources

20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure

Current Opinion in Nephrology and Hypertension, 2001
The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, vasoactivity and modulation of ion transport and mediation/modulation of the effects of vasoactive hormones, such as angiotensin II and endothelin, underscore their importance to renal vascular mechanisms and electrolyte excretion.
J C, McGiff, J, Quilley
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Epoxyeicosatrienoic acids, cell signaling and angiogenesis

Prostaglandins & Other Lipid Mediators, 2007
Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia. The activation of CYP epoxygenases in endothelial cells is an important step in the vasodilatation that has been attributed to the endothelium ...
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