Results 71 to 80 of about 3,445 (173)

CE methods for charge variant analysis of mAbs and complex format biotherapeutics

ELECTROPHORESIS, Volume 45, Issue 15-16, Page 1295-1306, August 2024.
Abstract Charge heterogeneity analysis of monoclonal antibodies (mAbs) and complex formats, such as bispecifics, is crucial for therapeutic applications. In this study, we developed two capillary electrophoresis (CE)‐based methods, capillary zone electrophoresis (CZE) and imaged capillary isoelectric focusing (iCIEF), for analyzing a broad spectrum of ...
Maximilian Meudt, Martin Pannek, Nina Glogowski, Fabian Higel, Katharina Thanisch, Matthias J. Knape   +5 more
wiley   +1 more source

ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats

Journal of Veterinary Internal Medicine, Volume 38, Issue 4, Page 1982-2007, July/August 2024.
Abstract Management of immune thrombocytopenia (ITP) in dogs and cats is evolving, but there are no evidence‐based guidelines to assist clinicians with treatment decisions. Likewise, the overall goals for treatment of ITP have not been established. Immunosuppressive doses of glucocorticoids are the first line treatment, but optimal treatment regimens ...
Dana N. LeVine, Robert Goggs, Barbara Kohn, Andrew J. Mackin, Linda Kidd, Oliver A. Garden, Marjory B. Brooks, Erin R. B. Eldermire, Anthony Abrams‐Ogg, Elizabeth H. Appleman, Todd M. Archer, Domenico Bianco, Shauna L. Blois, Benjamin M. Brainard, Mary Beth Callan, Claire L. Fellman, Jillian M. Haines, Anne S. Hale, Alice A. Huang, John M. Lucy, Shana K. O'Marra, Elizabeth A. Rozanski, John M. Thomason, Jenny E. Walton, Helen E. Wilson   +24 more
wiley   +1 more source

Could We Know epsilon-Aminocaproic Acid Level During Cardiopulmonary Bypass?

, 1998
Elliott Bennett‐Guerrero, Michael G. Mythen   +1 more
  +5 more sources

Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.

PLoS ONE, 2015
BackgroundRoutine use of antifibrinolytic agents in spine surgery is still an issue of debate.ObjectiveTo gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon ...
Meng Wang, Xin-Feng Zheng, Lei-Sheng Jiang   +2 more
doaj   +1 more source

Identity verification of monoclonal antibodies by triple injection capillary zone electrophoresis

Journal of Separation Science, Volume 47, Issue 11, June 2024.
This paper presents an approach based on triple injection capillary zone electrophoresis for identification of monoclonal antibodies. The analyte to be identified is injected between two zones of a known reference. The distances between the reference zones (plug I and III) and the target zone (plug II) are adjusted by partial electrophoresis of the ...
Johan A. Carlsson, Maria Löfgren, Ahmad Amini   +2 more
wiley   +1 more source

Abdominal trauma in dogs 2. management [PDF]

, 2018
Trauma represents a big challenge for emergency doctors both in human and veterinary medicine. There have been great advancements in trauma medicine in people and these often provide an inspiration for veterinary surgeons.
Cortellini, S, Humm, K R
core   +1 more source

A novel ITGA2B double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat

Journal of Veterinary Internal Medicine, Volume 38, Issue 3, Page 1408-1417, May/June 2024.
Abstract Background Glanzmann's thrombasthenia (GT) is a congenital platelet disorder affecting approximately 1:1 000 000 people globally and characterized by impaired platelet aggregation and clot retraction. Autosomal recessive, loss‐of‐function, variants in ITGA2B or ITGB3 of the αIIbβ3 receptor cause the disease in humans.
Victor N. Rivas, Avalene W. K. Tan, Meg Shaverdian, Nghi P. Nguyen, Jalena R. Wouters, Joshua A. Stern, Ronald H. L. Li   +6 more
wiley   +1 more source

Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta‐analysis [PDF]

, 2019
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the relative efficacy of pharmacological interventions for preventing blood loss in elective primary or revision hip or knee replacement, and to identify
Champaneria, R, Doree, C, Estcourt, Lise, Gibbs, VN, Palmer, Antony   +4 more
core   +2 more sources

Multi‐dimensional technology – Recent advances and applications for biotherapeutic characterization

Journal of Separation Science, Volume 47, Issue 5, March 2024.
This review provides an overview of the latest advancements and applications in multi‐dimensional liquid chromatography coupled with mass spectrometry (mD‐LC‐MS), covering aspects such as inter‐laboratory studies, digestion strategy, trapping column, and multi‐level analysis.
Thomas Bouvarel, Julien Camperi, Davy Guillarme   +2 more
wiley   +1 more source

ERAS for Cardiac Surgery: Development of a Clinical Practice Guideline for Antifibrinolytic Administration in Cardiac Surgery [PDF]

, 2022
Enhanced Recovery After Surgery (ERAS) guidelines are multimodal perioperative care pathways based on evidence-based practice to promote faster recovery after surgical procedures.
Foltz, Christopher T, Lawson, Katonya C
core   +1 more source