Results 1 to 10 of about 18,841 (129)

Is Clostridium perfringens epsilon toxin associated with multiple sclerosis? [PDF]

Mult Scler, 2023
Clostridium perfringens epsilon toxin is associated with enterotoxaemia in livestock. More recently, it is proposed to play a role in multiple sclerosis (MS) in humans. Compared to matched controls, strains of C. perfringens which produce epsilon toxin are significantly more likely to be isolated from the gut of MS patients and at significantly higher
Titball RW, Lewis N, Nicholas R.
europepmc   +3 more sources

The pore structure of Clostridium perfringens epsilon toxin. [PDF]

Nat Commun, 2019
AbstractEpsilon toxin (Etx), a potent pore forming toxin (PFT) produced by Clostridium perfringens, is responsible for the pathogenesis of enterotoxaemia of ruminants and has been suggested to play a role in multiple sclerosis in humans. Etx is a member of the aerolysin family of β-PFTs (aβ-PFTs).
Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M.   +7 more
europepmc   +8 more sources

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

PLoS Pathog, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Linden JR, Flores C, Schmidt EF, Uzal FA, Michel AO, Valenzuela M, Dobrow S, Vartanian T.   +7 more
europepmc   +3 more sources

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens. [PDF]

Vet Res, 2020
AbstractThe pore-forming protein epsilon toxin (Etx) from Clostridium perfringens produces acute perivascular edema affecting several organs, especially the brain and lungs. Despite the toxin evident effect on microvasculature and endothelial cells, the underlying molecular and cellular mechanisms remain obscure.
Dorca-Arévalo J, Dorca E, Torrejón-Escribano B, Blanch M, Martín-Satué M, Blasi J.   +5 more
europepmc   +7 more sources

Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives. [PDF]

Int J Pharm, 2017
Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore ...
Robinson TM, Jicsinszky L, Karginov AV, Karginov VA.   +3 more
europepmc   +4 more sources

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis. [PDF]

Mult Scler, 2019
Background: It was recently reported that, using Western blotting, some multiple sclerosis (MS) patients in the United States had antibodies against epsilon toxin (Etx) from Clostridium perfringens, suggesting that the toxin may play a role in the disease.
Wagley S, Bokori-Brown M, Morcrette H, Malaspina A, D'Arcy C, Gnanapavan S, Lewis N, Popoff MR, Raciborska D, Nicholas R, Turner B, Titball RW.   +11 more
europepmc   +6 more sources

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +30 more sources

A small bioactive glycoside inhibits epsilon toxin and prevents cell death.

Dis Model Mech, 2019
ABSTRACT Clostridium perfringens epsilon toxin (Etx) is categorized as the third most lethal bioterrorism agent by the Centers for Disease Control and Prevention (CDC), with no therapeutic counter measures available for humans. Here, we have developed a high-affinity inhibitory compound by synthesizing and evaluating the structure ...
Shivappagowdar A, Pati S, Narayana C, Ayana R, Kaushik H, Sah R, Garg S, Khanna A, Kumari J, Garg L, Sagar R, Singh S.   +11 more
europepmc   +4 more sources

Histidine residues in Clostridium perfringens epsilon toxin [PDF]

FEMS Microbiology Letters, 1987
Clostridium perfringens epsilon toxin was inactivated by ethoxyformic anhydride. A histidyl residue in the toxin was carbethoxylated under the conditions in which the toxin was completely inactivated, whereas tyrosyl residues were not affected. The toxin inactivated by ethoxyformic anhydride (EFA) was reactivated by treatment with hydroxylamine.
Jun Sakurai, Masahiro Nagahama
openaire   +2 more sources

Revisiting the STEC Testing Approach: Using espK and espV to Make Enterohemorrhagic Escherichia coli (EHEC) Detection More Reliable in Beef [PDF]

, 2016
Current methods for screening Enterohemorrhagic Escherichia coli (EHEC) O157 and non-O157 in beef enrichments typically rely on the molecular detection of stx, eae, and serogroup-specific wzx or wzy gene fragments.
Beutin, Lothar, Billet, Isabelle, Chaves, Byron D., Delannoy, Sabine, Delaval, Jose, Fach, Patrick, Ison, Sarah A., Webb, Hattie E.   +7 more
core   +4 more sources