Results 141 to 150 of about 1,305,585 (286)

Electrical controlled rheology of a suspension of weakly conducting particles in dielectric liquid [PDF]

, 2006
The properties of suspensions of fine particles in dielectric liquid (electrorheological fluids) subjected to an electric field lead to a drastic change of the apparent viscosity of the fluid. For high applied fields (~ 3-5 kV/mm) the suspension congeals
Ayela, F., Foulc, J. -N., Guegan, Quentin, Tillement, O.   +3 more
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Understanding the Role of Phosphoinositide 3-Kinase and its Function as a Driving Force behind the ER Stress Response in Fibrostenotic Crohn’s Disease-affected Ileal Smooth Muscle Cells [PDF]

, 2018
Crohn’s disease (CD) affects about 780,000 people in the United States alone, and it is estimated that 6-15 per 100,000 persons will receive a diagnosis of this disease each year.
Yadav, Prashant
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Oxidative stress specifically downregulates survivin to promote breast tumour formation. [PDF]

, 2013
BackgroundBreast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types.
Braga, M, Chaudhuri, G, Li, SA, Parveen, M, Pervin, S, Singh, R, Tran, L, Urman, R   +7 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Obesity and ER Stress

The Korean Journal of Obesity, 2011
비만은 비정상적인 또는 과다한 지방의 축적에 따른 건 강의 위협상태로 정의된다. 이미 전 세계적으로 5번째로 많 은 사망요인으로 보고된 비만에 의해 매년 적어도 280만명 이상의 성인이 사망한다. 세계보건기구 (WHO)의 2008년도 보고서에 따르면, 전 세계적으로 약 15억의 성인이 과체중 을 보이며, 그 중 5억명이 비만인구로 분류된다. 이와 같은 비만은 특히 고지방, 고염류, 고탄수화물의 음식 섭취와 도 시화에 따른 운동부족에 따른 섭취한 열량과 소모한 열량의 불균형을 그 근본적 원인으로 판단할 수 있다. 비만은 또한 당뇨병의 44%, 심혈관 질환의 23%, 그리고 기타 비만관련 암질환의 7~40%의 발병원인으로 보고되고
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

ER stress shapes muscle

The Journal of Cell Biology, 2005
On page 555, Nakanishi et al. show that ER stress triggers apoptosis during muscle development. It is the ER stress pathway's first appearance in a nonpathological context. As muscle precursor cells called myoblasts differentiate, they fuse into multinucleated myotubes.
openaire   +2 more sources