Results 151 to 160 of about 225,463 (263)

Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy. [PDF]

Chin Med
Wang J, Zhang W, Yang L, Zhong X, Ou J, Iyaswamy A, Gu X, Yang C, Guo B, Shi M, Wang J.   +10 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy. [PDF]

Mol Biomed
Zierke L, Gischke M, Sendler M, Weiss FU, Ribback S, Skowronek D, Rath M, Völzke H, Lerch MM, Aghdassi AA.   +9 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Ubiquitin-specific peptidase-19 links TDP-43 aggregation to ER stress. [PDF]

Proc Natl Acad Sci U S A
Yan Y, Wang X, Jeon H, Kee TR, Tran KD, Lee H, Zhao X, Liu T, Wing SS, Woo JA, Kang DE.   +10 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

ATF4 Is Dispensable for Spermatogenesis but Protective Against ER Stress Under Normal Conditions. [PDF]

Biology (Basel)
Zhang M, Wu Z, Teng Y, Zhu H, Dai P.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Neuroprotective role of NRF2 activation against ER Stress-Mediated apoptosis in obstructive sleep apnea. [PDF]

J Biol Chem
Zhong P, Zhuge S, Tu Y, Li J, Xu Y, Tsague Mbiada Meffo, Ke Y, Liu J, Xu L, Gao F, Peng X, Wu T, Pan Y, Xue Q, Zheng W, Li X, Yu C, Cai X.   +17 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source