Results 151 to 160 of about 1,308,915 (353)
Misfolding of Mutated Vasopressin Causes ER-Retention and Activation of ER-Stress Markers in Neuro-2a Cells [PDF]
, 2011 Zhongyu Yan
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cocaine-mediated microglial activation involves the ER stress-autophagy axis
, 2015 Ming‐Lei Guo +6 more
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Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma [PDF]
, 2015 Paola Giglio +4 more
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Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes [PDF]
, 2014 In a previous study we reported the presence of a large conductance K+ channel in the membrane of endoplasmic reticulum (ER) from rat hepatocytes.
Eliassi, Afsaneh +3 more
core
The Korean Journal of Obesity, 2011 비만은 비정상적인 또는 과다한 지방의 축적에 따른 건 강의 위협상태로 정의된다. 이미 전 세계적으로 5번째로 많 은 사망요인으로 보고된 비만에 의해 매년 적어도 280만명 이상의 성인이 사망한다. 세계보건기구 (WHO)의 2008년도 보고서에 따르면, 전 세계적으로 약 15억의 성인이 과체중 을 보이며, 그 중 5억명이 비만인구로 분류된다. 이와 같은 비만은 특히 고지방, 고염류, 고탄수화물의 음식 섭취와 도 시화에 따른 운동부족에 따른 섭취한 열량과 소모한 열량의 불균형을 그 근본적 원인으로 판단할 수 있다. 비만은 또한 당뇨병의 44%, 심혈관 질환의 23%, 그리고 기타 비만관련 암질환의 7~40%의 발병원인으로 보고되고
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]
, 2019 BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin +2 more
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