Results 171 to 180 of about 1,308,915 (353)

Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib [PDF]

, 2013
Shingen Nakamura, Hirokazu Miki, Shinsuke Kido, Ayako Nakano, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Keiichiro Watanabe, Takeshi Harada, Shiro Fujii, Kyoko Takeuchi, Kumiko Kagawa, Shuji Ozaki, Toshio Matsumoto, Masahiro Abe   +14 more
openalex   +1 more source

OSMI-1 Enhances TRAIL-Induced Apoptosis through ER Stress and NF-κB Signaling in Colon Cancer Cells [PDF]

, 2021
Su-Jin Lee, Daeun Lee, Soo‐Young Choi, Oh‐Shin Kwon   +3 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells

Physiological Reports
Pancreatic β‐cell mass is a critical determinant of insulin secretion. Severe endoplasmic reticulum (ER) stress causes β‐cell apoptosis; however, the mechanisms of progression and suppression are not yet fully understood.
Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaji   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway

, 2017
Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Yao   +7 more
openalex   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

iRhom1 regulates proteasome activity via PAC1/2 under ER stress [PDF]

, 2015
WonJae Lee, YoungDoo Kim, Jisu Park, Sangmi Shim, Ji‐Eun Lee, Se-Hoon Hong, Hye-Hyun Ahn, Huikyong Lee, Yong‐Keun Jung   +8 more
openalex   +1 more source

Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies

, 2021
Andrii Puzyrenko, Elizabeth R. Jacobs, Yunguang Sun, Juan C. Felix, Yuri Sheinin, Linna Ge, Shuping Lai, Qiang Dai, Benjamin N. Gantner, Rahul Nanchal, Paula E. North, Pippa Simpson, Hallgeir Rui, Ivor J. Benjamin   +13 more
openalex   +1 more source

Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy [PDF]

, 2022
Rashedul Alam, Mohammad Fazlul Kabir, Hyung‐Ryong Kim, Han–Jung Chae   +3 more
openalex   +1 more source