Results 191 to 200 of about 225,463 (263)

Transient ER stress cell-autonomously promotes beta cell cycling in mice. [PDF]

Diabetologia
Bourgeois S, Van Mulders A, Heremans Y, Leuckx G, Willems L, Coenen S, Degroote L, Pierreux J, Kancheva D, Scheyltjens I, Movahedi K, Carlotti F, de Koning E, Yi X, Vinci C, Tong Y, Cnop M, Heimberg H, De Leu N, Staels W.   +19 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress. [PDF]

Cell Death Dis
Lin M, Zhang H, Chen S, Zhang J, Tang C, Song X, Zhou J, Xu Z, Mu Y, Zeng H, Yang C, Yu C, Xu C.   +12 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Targeting LIPA with ERX-41 Induces ER Stress and Inhibits Tumor Progression in Inflammatory Breast Cancer. [PDF]

Biomolecules
Fuentes Z, Sharma G, Romo BA, Gopalam R, Nassar KM, Ramirez P, Mejia N, Chen CY, Elmore S, Neal H, Nagandla H, Subbarayalu P, Pratap UP, Thomas C, Ahn JM, Raj GV, Viswanadhapalli S, Vadlamudi RK.   +17 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

ER Stress Is Associated with a "Mesenchymal Drift" in an Anaplastic Thyroid Carcinoma Cell Line. [PDF]

Cancers (Basel)
Lofrumento DD, Miraglia A, Treglia AS, De Nuccio F, Nicolardi G, Garbi C, Di Jeso B.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Single cell profiling of ER stress in coronary artery disease and therapeutic mechanisms of Ginkgo biloba extract. [PDF]

Sci Rep
Zhao FJ, Wang F, Qin C, Ye LL.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source