Results 221 to 230 of about 1,308,915 (353)

Deficiency of PTEN Confers Hypersensitivity to Fatty Acid-Mediated ER Stress in Transformed Hepatocytes. [PDF]

Int J Mol Sci
Yassin O, Darawshi O, Wang F, Zhang Y, Abbas A, Merrick WC, Cheung W, Antoniou A, Pattanayak SP, Tirosh B.   +9 more
europepmc   +1 more source

ER stress and cell fate: FKBP2 regulates proinsulin folding and α- vs. β cell differentiation via NFAT and HDAC9 [PDF]

Edyta Urbaniak, Maja Baginska, Wojciech J. Szlachcic, Małgorzata Grabowska, E. G. Shcheglova, Artur Jankowski, Michał Marzec, Malgorzata Borowiak   +7 more
openalex   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Podocyte-Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease. [PDF]

J Extracell Vesicles
Liu Z, Liu X, Wen X, Yan S, He M, Xu J, Zhan Z, Zhu H, Tan H, Jia N, Liu Y.   +10 more
europepmc   +1 more source

Calcium signalling and ER stress in insulin resistance and atherosclerosis

, 2016
Lale Özcan, Ira Tabas
openalex   +2 more sources

ER stress and β cell death — therapeutic approach to combat ER stress

Folia Pharmacologica Japonica, 2014
Takashi, Hara, Fumihiko, Urano
openaire   +3 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Unresolved questions on the GADD45GIP1-RPL35 axis in osteosarcoma: mechanistic links to ER stress and therapeutic targeting. [PDF]

Cancer Cell Int
Qi L, Gu Q, Yang D, Ye Z, Li D.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Myrrh ameliorates endometriosis by enhancing ER stress-related apoptotic cell death. [PDF]

Exp Ther Med
Kim BS, Cho M, Han JH, Jin JS, Bae SJ, Jo Y, Ryu D, Joo Y, Kim SB, Joo J, Kim I, Ha KT.   +11 more
europepmc   +1 more source