Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells [PDF]
, 2018 Recent evidences indicate that triple-negative breast cancer (TNBC) cells with a mesenchymal phenotype show a basal activation of the unfolded protein response (UPR) that increases their sensitivity to endoplasmic reticulum (ER) stress although the ...
Cano-González, Ana +4 more
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The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise
International Journal of Vascular Medicine, 2017 Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion.
Junyoung Hong +3 more
doaj +1 more source
Differential Activation of ER Stress Signal Pathway s Contributes to Palmitate-Induced Hepatocyte Lipoapoptosis [PDF]
, 2016 Saturated free fatty acids-induced hepatocyte lipoapoptosis plays a pivotal role in non-alcoholic steatohepatitis. Theactivation of endoplasmic reticulum (ER) stress isinvolved in hepatocyte lipoapoptosis induced by thesaturated free fatty acidpalmitate (
Yao, Fuli
core +1 more source
Molecular Medicine, 2020 Background Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mechanism of cerebral I/R injury ...
Xiaowei Sun +9 more
doaj +1 more source
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]
, 2019 BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin +2 more
core +1 more source
Endocrine Journal, 2009 It is known that endoplasmic reticulum (ER) stress is provoked under diabetic conditions and is possibly involved in the development of insulin resistance. In this study, using ER stress-activated indicator (ERAI) transgenic mice which express green fluorescent protein under ER stress conditions, we directly evaluated the effects of a diabetic agent ...
Kazutomi, Yoshiuchi +9 more
openaire +3 more sources
Taurine reduces ER stress in C. elegans [PDF]
, 2010 Background ER stress is a strong indicator of whether or not a cell is undergoing physiological stress. C. elegans is a practical system of characterizing the effect of ER stress at the in vivo or organismal level.
Hye Kim, Chang-Hee Do, Dong Lee
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ER-Mitochondrial Communication Gets Stressful
Science Translational Medicine, 2014 An increase in contacts between the endoplasmic reticulum and mitochondria with a concomitant influx of calcium ions into liver cells may contribute to obesity-induced metabolic syndrome.
openaire +2 more sources
Environmental change rate and dispersion pattern modulate the dynamics of evolutionary rescue of the cyanobacterium Microcystis aeruginosa [PDF]
, 2018 The rate of biodiversity loss is so high that some scientists affirm that we are being witnesses of the sixth mass extinction. In this situation, it is necessary to ask the following question: can the organisms be able to resist the environmental changes
Bañares-España, Elena +5 more
core
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
core +2 more sources