Results 1 to 10 of about 6,026 (227)

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes. [PDF]

Immunology
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a polymorphic enzyme that shapes the peptide repertoire presented by MHC class I molecules and can regulate adaptive immune responses in cancer and autoimmunity.
Nikopaschou M, Samiotaki M, Kannavou A, Angelis NV, Tsitsilonis O, Panayotou G, Stratikos E.   +6 more
europepmc   +4 more sources

Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine [PDF]

Frontiers in Immunology
IntroductionUlcerative colitis (UC) is a life-threatening heterogeneous condition characterized by inflammation of the colon. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is essential for antigen processing and immune regulation, however, its specific ...
Bushra Riaz, Bushra Riaz, Hye-Myung Ryu, S. M. Shamsul Islam, Rahar Babita, Je Kyung Seong, Je Kyung Seong, Je Kyung Seong, Ho Lee, Eunjoo H. Lee, Seonghyang Sohn, Seonghyang Sohn, Seonghyang Sohn   +12 more
doaj   +3 more sources

The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis [PDF]

BMC Infectious Diseases
Background Genetic variations in endoplasmic reticulum aminopeptidase (ERAP1, ERAP2) genes are associated with the pathogenesis of multiple diseases, including infectious diseases.
Shi-Hong Su, Xue-Qian Cai, Yong-Huai Li, Ai-Hui Xu, Qian Huang, Hua Niu, Qing-Hai You, Geng-Yun Sun   +7 more
doaj   +3 more sources

Effective Reduction of Transgene-Specific Immune Response With rAAV Vectors Co-Expressing miRNA-UL112-5p or ERAP1 shRNA. [PDF]

J Cell Mol Med
Recombinant adeno‐associated virus (rAAV) has emerged as one of the best gene delivery vectors for human gene therapy in vivo. However, the clinical efficacy of rAAV gene therapy is often hindered by the host immune response against its transgene ...
Huang X, Wang X, Sun Y, Xie X, Xiao L, Xu Y, Yan Q, Xu X, Li L, Xu W, Weng W, Wu W, Xie X, Dai C, Diao Y.   +14 more
europepmc   +3 more sources

Unveiling the impact of ERAP1 and ERAP2 on migration, angiogenesis and ER stress response [PDF]

Frontiers in Cell and Developmental Biology
Recent studies have investigated the key roles exerted by ERAP1 and ERAP2 in maintaining cellular homeostasis, emphasizing their functions beyond traditional antigen processing and presentation.
Irma Saulle, Irma Saulle, Alessandra Velia Vitalyos, Daniel D’Agate, Mario Clerici, Mario Clerici, Mara Biasin   +6 more
doaj   +3 more sources

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population [PDF]

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed.
Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak   +8 more
doaj   +3 more sources

Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB).
Patrizia Tempora, Silvia D’Amico, Paula Gragera, Verena Damiani, Kamila Krol, Valentina Scaldaferri, Kirti Pandey, Shanzou Chung, Valeria Lucarini, Ezio Giorda, Marco Scarsella, Gabriele Volpe, Marco Pezzullo, Cristiano De Stefanis, Valentina D’Oria, Lorenzo De Angelis, Roberto Giovannoni, Maria Antonietta De Ioris, Ombretta Melaiu, Anthony W. Purcell, Franco Locatelli, Doriana Fruci   +21 more
doaj   +3 more sources

ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia [PDF]

Molecular Genetics & Genomic Medicine
Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.
Xin Li, Jia Bao, Liya Ai, Fan‐Rui Yang, Bo Yu, Yan‐Ping Huang, Na Li, Wen‐Yuan Ding, Zhi‐Qiang Sun, Xin‐Xiang Lv, Jian‐Wen Han   +10 more
doaj   +3 more sources

Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease. [PDF]

Mamm Genome
Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility.
Win LK, Cheng G, Ashton JJ, Kadhim AZ, Green Z, Beattie RM, Ennis S.   +6 more
europepmc   +2 more sources

Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis. [PDF]

JAMA Dermatol
Importance Frontal fibrosing alopecia (FFA) is an inflammatory and scarring form of hair loss of increasing prevalence that most commonly affects women.
Rayinda T, Dand N, McSweeney SM, Christou E, Ung CY, Stefanato CM, Fenton DA, Harries M, Palamaras I, Tidman A, Holmes S, Koutalopoulou A, Ardern-Jones M, Kaur M, Papanikou S, Chasapi V, Vañó-Galvan S, Saceda-Corralo D, Melián-Olivera A, Azcarraga-Llobet C, Lobato-Berezo A, Bustamante M, Sunyer J, Starace MVR, Piraccini BM, Wiss IP, Senna MM, Singh R, Hillmann K, Kanti-Schmidt V, Blume-Peytavi U, McGrath JA, Simpson MA, Tziotzios C.   +33 more
europepmc   +2 more sources