Results 91 to 100 of about 6,026 (227)

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Life, 2021
Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska, Łukasz Matusiak, Joanna Narbutt, Alekandra Lesiak, Piotr Kuna, Andrzej Wiśniewski, Piotr Kuśnierczyk   +6 more
doaj   +1 more source

Structural bases for MHC class I peptide selection and neoepitope formation [PDF]

, 2018
One task of the immune system is to distinguish between healthy cells and altered cells due to viruses or cancers. To achieve this CD8+ T-cells are constantly monitoring the Major histocompatibility class I (MHC-I) complexes expressed on all nucleated ...
Hafstrand, Ida
core   +1 more source

Tamarixetin Suppresses Colorectal Cancer Progression by Targeting DPP7‐Mediated WNT3A/β‐Catenin Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Colorectal cancer (CRC) patients have had limited benefits from conventional chemotherapy, highlighting the need for improved therapeutic strategies. Natural compounds have emerged as promising alternatives due to their potent anti‐cancer properties and reduced side effects.
Peng Ouyang, Jin Gong, Jinlin Nie, Sridhar Kandala, Yangdong Shi, Yao Tian, Zhijing Zhang, Sifu Fang, Fan Pan, Lin Qiu, Zhen Bao   +10 more
wiley   +1 more source

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism

OncoImmunology, 2017
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components.
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, Angelika B. Riemer   +9 more
doaj   +1 more source

The differential placental expression of ERp44 and pre-eclampsia; association with placental zinc, the ERAP1 and the renin-angiotensin-system

Placenta, 2023
Introduction Endoplasmic reticulum resident protein 44 (ERp44) is a zinc-metalloprotein, regulating Endoplasmic reticulum aminopeptidase 1 (ERAP1) and Angiotensin II (Ang II). We explored placental ERp44 expression and components of the renin-angiotensin-
Rhea Raghu, L. Kurlak, Eun D Lee, H. Mistry   +3 more
semanticscholar   +1 more source

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape [PDF]

, 2014
Introduction: Transposable element (TE) derived sequences comprise half of our genome and DNA methylome, and are presumed densely methylated and inactive.
Cho, Stephanie, Costello, Joseph F., Farnham, Peggy J., Gascard, Philippe, Hirst, Martin, Hong, Chibo, Kadlecek, Theresa, Kamoh, Baljit, Lee, Hyung Joo, Li, Daofeng, Ligon, Keith L., Lowdon, Rebecca, Madden, Pamela A.F., Maire, Cecile L., Marra, Marco A., Moore, Richard, Mungall, Andrew J., O’Geen, Henriette, Sigaroudinia, Mahvash, Tam, Angela, Tlsty, Thea D., Wang, Ting, Weiss, Arthur, Xie, Mingchao, Xing, Xiaoyun, Zhang, Bo, Zhou, Xin   +26 more
core   +1 more source

Decoding MHC loss: Molecular mechanisms and implications for immune resistance in cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Tumour cells evade immune surveillance by downregulating MHC expression through transcriptional repression, lysosomal degradation and post‐translational modifications. Pharmacological agents interventing epigenetic and metabolic can upregulate MHC expression and improve T cell activation.
Pei Lin, Yunfan Lin, Xu Chen, Xinyuan Zhao, Li Cui   +4 more
wiley   +1 more source

A Review of the Molecular and Genetic Foundations of Ankylosing Spondylitis [PDF]

, 2012
Ankylosing Spondylitis (AS) is an autoimmune disease that occurs in an adult-onset or juvenile-onset form. The symptoms, severity, and prevalence of this disease vary according to sex, age, and race.
Dowlearn, Emily
core  

Scotland Registry for Ankylosing Spondylitis (SIRAS) – Protocol [PDF]

, 2016
Funding SIRAS was funded by unrestricted grants from Pfizer and AbbVie. The project was reviewed by both companies, during the award process, for Scientific merit, to ensure that the design did not compromise patient safety, and to assess the global ...
Dean, Linda E, Gibson, Jane, Hunter, John, Jones, Elizabeth A, Jones, Gareth T, MacDonald, Alan G, Macfarlane, Gary J, Marshall, David, McEntegart, Anne, Munro, Robin, Sturrock, Roger D   +10 more
core   +1 more source

Analysis of Hyperexpanded T Cell Clones in SARS‐CoV‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 vaccine‐associated liver injury (SVALI) is a rare event and its pathophysiology remains unclear. Previous studies have found an oligoclonal CD8+ T cell infiltrate and SARS‐CoV‐2 spike antigen‐specific T cells in the liver of patients with SVALI. Therefore, we aimed to characterise the immune infiltrate in a liver
Sarp Uzun, Asmita Pant, Ewelina Bartoszek, Paul Gueguen, Stefan Frei, Hélène Heusler, Ilaria Arborelli, Carl Philipp Zinner, Neşe Karadağ Soylu, Benedetta Terziroli Beretta‐Piccoli, Cumali Efe, Matthias S. Matter   +11 more
wiley   +1 more source