Results 101 to 110 of about 6,026 (227)

The epidemiology of childhood psoriasis: a scoping review [PDF]

, 2016
Psoriasis is an inflammatory noncommunicable skin disease that affects both adults and children. At present, the epidemiology and natural history of psoriasis are not widely understood.
Adaji, Enemona, Burden-Teh, Esther, Grindlay, Douglas J.C., Murphy, Ruth, Ratib, Sonia, Thomas, Kim S.   +5 more
core   +2 more sources

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Mendelian randomization analysis identifies ERAP1 and IL23R as potential drug targets for ankylosing spondylitis.

Life Science
BACKGROUND Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and pelvis, leading to ankylosis, stiffness, and reduced quality of life. Despite therapeutic advances, identifying novel drug targets remains critical.
Wenquan Wu, Kewang Sun, Chen Zhang, Qiang Zhang, Xiangyan Huang   +4 more
semanticscholar   +1 more source

Autoimmune and autoinflammatory mechanisms in uveitis [PDF]

, 2014
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult ...
A Amadi-Obi, A Arida, A Cortes, A Fox, A Jager, A Peters, A Rothova, AC Anderson, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AG Commodaro, AG Commodaro, AJ St. Leger, AK Denniston, AK Denniston, AL Oberg, Andrew D. Dick, B Bodaghi, B Engelhardt, BJ Raveney, BJ Raveney, BJ Raveney, BS Sheridan, C Broderick, C Terrada, C-C Chan, CC Murphy, CEI Janssen, Chi-Chao Chan, CJ Calder, CJ Chu, CJ Chu, D Atan, D Atan, D Atan, D Atan, D Banerjee, D Luger, D Perra, DA Carter, DA Copland, DA Copland, DA Copland, DA Copland, DA Jabs, DC Wraith, DF Martin, DJ Hankey, DJ Kilmartin, DL Turner, E Furusato, EB Gouveia, EC Kerr, EC Kerr, ED Mandelcorn, EF Foxman, EF Remmers, EJ Wherry, F An, F Chen, G Geri, GJ Wright, GJ Wright, GR Wallace, H Keino, H Mielants, H. Nida Sen, HL Rosenzweig, HL Rosenzweig, HL Rosenzweig, HM Cherwinski, HN Sen, IJ Crane, J Bauer, J Candia, J Chen, J Correale, JA Todd, JB Fordham, JC Wei, JF Bach, JJ Kuiper, JP Sherlock, JT Rosenbaum, JV Forrester, JV Forrester, JV Forrester, JV Forrester, K Gocho, KG Anderson, KH Sonoda, KM Murphy, KM Murphy, L Jostins, L Mao, Lai Wei, Lindsay B. Nicholson, LK Grange, LK Mackay, LM Wakim, LM Wakim, LP Schewitz, LV Rizzo, M Chen, M Cordero-Coma, M Deckert, M Greter, M Khairallah, M Pepper, MC Jenmalm, MG Netea, MJ Mattapallil, MJ Robertson, MS Suttorp-Schulten, N Hashida, N Mizuki, N Taylor, N Yosef, NA Rao, O Tomkins-Netzer, P Kivisäkk, P Yang, P Zamiri, PA Kurz, PB Medawar, PP Sfikakis, R Banchereau, R Gold, R Plumlee Courtney, R Ramesh, R Shechter, R Zhang, R Zhou, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, RB Nussenblatt, Richard W. Lee, RJ Snelgrove, RK Agarwal, RM Hoek, Robert B. Nussenblatt, RP Nair, RR Caspi, RR Caspi, RR Caspi, RR Caspi, RW Darrell, RW Lee, RW Lee, RW Lee, RW Read, RW Read, S Horie, S Hou, S Hou, S Jawad, S Ohno, S Ooka, S Preston, S Sugita, S Sugita, S Sugita, S Sugita, S Yeh, S Zhang, SA Ramsey, SB Su, SC Bendall, SC Teoh, SJ Morrison, SL Masters, SM Islam, SM Sharma, SM Whitcup, SR Boyd, SR Taylor, SR Thurau, SR Thurau, SW McPherson, T Lambe, T Yoshimura, TA Manolio, TM Martin, U Kaufmann, VL Calder, W Chi, W Chi, WF Hickey, WW Soon, Y Fei, Y Kirino, Y Okunuki, Y Peng, Y Usui, YH Lee, Z Li, Z Tu   +203 more
core   +1 more source

Restoring Tumor Cell Immunogenicity Through Ion‐Assisted p53 mRNA Domestication for Enhanced In Situ Cancer Vaccination Effect

Advanced Science, Volume 12, Issue 14, April 10, 2025.
PRIZE, a P53‐repair nanosystem based on a virus‐mimicking nanostructure, delivers p53 mRNA into tumor cells, restoring P53 levels and enhancing immunogenicity. Its biomineralized structure stabilizes the mRNA, prolongs P53's half‐life, and precisely targets tumors.
Yan Liang, Jingge Zhang, Jinjin Wang, Yuhe Yang, Xinyu Tan, Shuguang Li, Zhenzhen Guo, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Kaixiang Zhang   +10 more
wiley   +1 more source

A large meta-analysis identifies genes associated with anterior uveitis

Nature Communications, 2023
Anterior Uveitis (AU) is the inflammation of the anterior part of the eye, the iris and ciliary body and is strongly associated with HLA-B*27. We report AU exome sequencing results from eight independent cohorts consisting of 3,850 cases and 916,549 ...
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tavé Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Regeneron Genetics Center, Eli A. Stahl, Giovanni Coppola   +22 more
doaj   +1 more source

iPSC‐derived human cortical organoids display profound alterations of cellular homeostasis following SARS‐CoV‐2 infection and Spike protein exposure

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Graphical representation of the study workflow. iPSC‐derived human cortical organoids (HCOs) at Day 40, were in vitro infected by SARS‐CoV‐2 or exposed to the Spike protein and viral infection/replication was assessed by a multidisciplinary approach using RT‐qPCR, TCID50, and immunofluorescence.
Gioia Cappelletti, Lorenzo Brambilla, Sergio Strizzi, Fiona Limanaqi, Valentina Melzi, Mafalda Rizzuti, Monica Nizzardo, Irma Saulle, Daria Trabattoni, Stefania Corti, Mario Clerici, Mara Biasin   +11 more
wiley   +1 more source

A novel allosteric driver mutation of β‐glucuronidase promotes head and neck squamous cell carcinoma progression through STT3B‐mediated PD‐L1 N‐glycosylation

MedComm, Volume 6, Issue 2, February 2025.
Liu et al. identified the specific mutation H351Q in β‐glucuronidase (GUSB) as a novel allosteric driver mutation, which facilitated the aberrant N‐glycosylation of PD‐L1 through increasing protein stability and mRNA transcripts of the STT3 oligosaccharyltransferase complex catalytic subunit B (STT3B).
Zhonglong Liu, Xiaoyan Meng, Xiao Tang, Jian Zhang, Zhiyuan Zhang, Yue He   +5 more
wiley   +1 more source

Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia

Iranian Journal of Public Health, 2019
Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of
Hamid DARGAHI, Mohammad Hossein NICKNAM, Mahroo MIRAHMADIAN, Mahdi MAHMOUDI, Saeed ASLANI, Maryam SADROSADAT, Robabeh GHODSSI-GHASSEMABADI, Ali Akbar AMIRZARGAR   +7 more
doaj   +1 more source

Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Knockdown of GLS in CRC cells enhanced the cytotoxicity of tumor‐infiltrated CD8+ T cells. This study further demonstrated that glutamate‐to‐glutathione (Glu‐GSH) flux, downstream of GLS, plays a key role in regulating antitumor immunity. Mechanistically, inhibition of the Glu‐GSH flux activated ROS‐related signaling pathways in tumor cells, thereby ...
Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang   +16 more
wiley   +1 more source