Results 131 to 140 of about 6,026 (227)

Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2012
Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for  AS susceptibility after HLA-B27.
Mahdi Mahmoudi   +8 more
doaj  

A Review of Ankylosing Spondylitis [PDF]

open access: yes, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

open access: yesChinese Medical Journal
. Background:. Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance.
Danyi Zou   +16 more
doaj   +1 more source

ERAP1 inhibitor development

open access: yes, 2018
ERAP1 has been associated with a set of immune-mediated diseases, including ankylosing spondylitis. Currently, there is no selective and potent ERAP1 inhibitor available that would allow in-depth research of its functions and roles in diseases. Therefore, the aim of this work is to apply fragment-based drug design approach for the development of such ...
openaire   +1 more source

Le mélanome et les polymorphismes associés au dysfonctionnement du système immunitaire [PDF]

open access: yes, 2012
La recherche biomédicale profite de plus en plus au développement des techniques de séquençage et d'analyse de l'ADN. Les coûts du séquençage ont drastiquement baissés au cours de ces dernières années et les genomes-wides associations studies (GWAS) ont ...
Naso, S.
core  

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function [PDF]

open access: yes, 2017
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis ...
Abdulkader, Rita   +573 more
core  

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

open access: yes, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama   +4 more
core   +1 more source

Geneticheskie prediktory ankiloziruyushchego spondilita

open access: yesКардиоСоматика, 2015
Анкилозирующий спондилит (АС) - хроническое воспалительное заболевание позвоночника (спондилит) и крестцово-подвздошных суставов (сакроилеит), нередко протекающее с поражением периферических суставов (артрит) и энтезисов (энтезит), а в ряде случаев ...
V. S Mordovskiy   +5 more
doaj  

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