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The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +4 more sources

Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma [PDF]

Analytical Cellular Pathology, 2015
The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta, Michelle Osse, Sandra Kolkman-Uljee, Gert Jan Fleuren, Ekaterina S. Jordanova   +4 more
doaj   +5 more sources

ERAP1 Activity Modulates the Immunopeptidome but Also Affects the Proteome, Metabolism, and Stress Responses in Cancer Cells. [PDF]

Mol Cell Proteomics
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I).
Nikopaschou M, Samiotaki M, Stylianaki EA, Król K, Gragera P, Raja A, Aidinis V, Chroni A, Fruci D, Panayotou G, Stratikos E.   +10 more
europepmc   +2 more sources

Expression and role of ERAP1 in placental tissues of preeclampsia

Hypertension in Pregnancy, 2020
Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot.
Yanyan Xu, Junjiao Wu, Jianbo Wu
doaj   +3 more sources

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Frontiers in Immunology, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos, Efstratios Stratikos   +3 more
doaj   +4 more sources

Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions. [PDF]

Front Cell Dev Biol
Introduction Endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) modulate a plethora of physiological processes for the maintenance of homeostasis in different cellular subsets at both intra and extracellular level.
Saulle I, Limanaqi F, Garziano M, Murno ML, Artusa V, Strizzi S, Giovarelli M, Schulte C, Aiello J, Clerici M, Vanetti C, Biasin M.   +11 more
europepmc   +2 more sources

The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis. [PDF]

Invest Ophthalmol Vis Sci
Purpose To investigate how ERAP1 and ERAP2 genotype combinations influence susceptibility and severity in birdshot chorioretinitis (BSCR), an HLA-A29–associated disease with variable visual outcomes.
Loeliger J, Gelfman S, Stahl EA, Moscati A, Bai X, Monnet D, Imikirene L, Kecili S, Tabary T, Cohen J, Brézin AP.   +10 more
europepmc   +2 more sources

Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection. [PDF]

Hum Mol Genet
Puumala virus (PUUV) infections can cause severe illnesses such as Hemorrhagic Fever with Renal Syndrome in humans. However, human genetic risk factors contributing to disease severity are still poorly understood.
Haapaniemi H, Strausz S, Tervi A, Jones SE, Kanerva M, FinnGen, Estonian Biobank Research Team, Abner E, Fors Connolly AM, Ollila HM.   +9 more
europepmc   +2 more sources

Shedding Light on the Role of ERAP1 in Axial Spondyloarthritis

Cureus, 2023
Spondyloarthritis (SpA) is a multifactorial chronic inflammatory disease affecting the axial skeleton (axSpA) and/or peripheral joints (p-SpA) and entheses.
M. A. Saad, A. B. Abdul-Sattar, I. Abdelal, Ahmed Baraka   +3 more
semanticscholar   +3 more sources

Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design. [PDF]

ACS Med Chem Lett
Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves the N-terminal amino acids of peptides, which can then bind onto major histocompatibility class I (MHC-I) molecules for presentation onto the cell surface, driving the activation of adaptive immune ...
Hryczanek RP, Hackett AS, Rowland P, Chung CW, Convery MA, Holmes DS, Hutchinson JP, Kitchen S, Korczynska J, Law RP, Lea JD, Liddle J, Lonsdale R, Neu M, Nickels L, Phillipou A, Rowedder JE, Schneck JL, Scott-Stevens P, Sheehan H, Tayler CL, Temponeras I, Tinworth CP, Walker AL, Wojno-Picon J, Young RJ, Lindsay DM, Stratikos E.   +27 more
europepmc   +2 more sources