Results 21 to 30 of about 6,026 (227)

First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease.

European Journal of Medicinal Chemistry
Inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) by small-molecules is being eagerly investigated for the treatment of various autoimmune diseases and in the field of immuno-oncology after its active involvement in antigen presentation and ...
Vasileios Fougiaxis, Valentina Barcherini, Milena M. Petrovic, Pierre Sierocki, Sandrine Warenghem, F. Leroux, Nour Bou Karroum, Fabien Petit-Cancelier, Vincent Rodeschini, Didier Roche, Benoit Deprez, R. Deprez-Poulain   +11 more
semanticscholar   +5 more sources

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion. [PDF]

Immunology
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Tian L, Zhang M, Guo Y, Chang S, Chen ZK, Zhou H.   +5 more
europepmc   +2 more sources

ERAMER: A novel in silico tool for prediction of ERAP1 enzyme trimming.

Journal of Immunological Methods
MHC class I pathway consists of four main steps: proteasomal cleavage in the cytosol in which precursor proteins are cleaved into smaller peptides, which are then transported into the endoplasmic reticulum by the transporter associated with antigen ...
Anas Al-Okaily, Razan Abu Khashabeh, Osama Alsmadi, Y. Ahmad, Iyad Sultan, A. Tbakhi, Pramod K Srivastava   +6 more
semanticscholar   +3 more sources

Functional ERAP1 Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of HLA-B27 in Taiwanese

Cells, 2022
Epistasis of ERAP1 single nucleotide variations (SNVs) and HLA-B27 has been linked to ankylosing spondylitis susceptibility (AS). The current study examined how prevalent ERAP1 allelic variants (SNV haplotypes) in Taiwan affect ERAP1 functions and AS ...
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen   +6 more
doaj   +1 more source

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source

Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides

Frontiers in Microbiology, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a processing enzyme of antigenic peptides presented to major histocompatibility complex (MHC) class I molecules.
Huanhuan Liu, Bingqi Hu, Junfeng Huang, Qin Wang, Feier Wang, Faming Pan, Liwen Chen   +6 more
doaj   +1 more source

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

Frontiers in Immunology, 2021
The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Loredana Cifaldi, Doriana Fruci   +13 more
doaj   +1 more source

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

Scientific Reports, 2021
Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response.
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos   +9 more
doaj   +1 more source

Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response. [PDF]

PLoS ONE, 2013
Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating ...
Yasser A Aldhamen, Sergey S Seregin, David P W Rastall, Charles F Aylsworth, Yuliya Pepelyayeva, Christopher J Busuito, Sarah Godbehere-Roosa, Sungjin Kim, Andrea Amalfitano   +8 more
doaj   +1 more source

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers

Frontiers in Immunology, 2021
Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components.
Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz, Piotr Kuśnierczyk   +10 more
doaj   +1 more source