Results 31 to 40 of about 6,026 (227)
ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]
The Journal of Immunology, 2014 Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou +3 more
openaire +2 more sources
Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
Türk Biyokimya Dergisi, 2022 Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA.
Akbulut Ekrem +2 more
doaj +1 more source
ERAP1 biology and assessment in Ankylosing Spondylitis [PDF]
Proceedings of the National Academy of Sciences, 2015 We read with interest the work of Reeves et al. on endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes found in Ankylosing Spondylitis (AS), and have several concerns about the study and its conclusions (1).
Robinson, Philip C., Brown, Matthew A.
openaire +3 more sources
Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer
BMC Cancer, 2023 Background ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding.
Marta Wagner +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: Psoriasis is a common immune-mediated hyperproliferative skin dysfunction with known genetic predisposition. Gene–gene interaction (e.g., between HLA-C and ERAP1) in the psoriasis context has been reported in various populations. As ERAP1 has
Chang Zhang +44 more
doaj +1 more source
The role of polymorphic ERAP1 in autoinflammatory disease [PDF]
Bioscience Reports, 2018 Autoimmune and autoinflammatory conditions represent a group of disorders characterized by self-directed tissue damage due to aberrant changes in innate and adaptive immune responses. These disorders possess widely varying clinical phenotypes and etiology; however, they share a number of similarities in genetic associations and environmental influences.
Reeves, Emma, James, Edward
openaire +5 more sources
ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses
BMC Immunology, 2022 Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined. We previously
Maja K. Blake +5 more
doaj +1 more source
Nature Communications, 2021 The endoplasmic-reticulum aminopeptidase ERAP1 processes peptides for antigen presentation. Here, the authors assess ERAP1 conformational states in solution, providing insight into the molecular mechanisms of ERAP1 substrate-length dependent catalytic ...
Zachary Maben +4 more
doaj +1 more source
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
doaj +1 more source
Ankylosing Spondylitis: a trade Off of HLA-B27, ERAP, and pathogen interconnections? Focus on Sardinia [PDF]
, 2019 The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies.
Cauli, A +5 more
core +2 more sources