ERAP1 and ankylosing spondylitis
Current Opinion in Immunology, 2013 The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affecting the stability and processing ...
Keidel, S +3 more
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Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis [PDF]
, 2012 Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe ...
Artieda, Marta +11 more
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The role of 39 psoriasis risk variants on age of psoriasis onset. [PDF]
, 2013 Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored.
Butler, Daniel +12 more
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An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes [PDF]
, 2018 The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides to the optimal size ...
Cauli, A +7 more
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Genetic susceptibility to feline infectious peritonitis in Birman cats. [PDF]
, 2013 Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal.
Golovko, Lyudmila +5 more
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Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues [PDF]
, 2016 Copyright © 2015 by the American College of Rheumatology. Objective To characterize the alterations, as well as their mechanisms, induced in the HLA-B27-bound peptidome expressed in live cells by the natural ERAP1 polymorphisms predisposing to ankylosing
Akram +35 more
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A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]
, 2019 Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia +14 more
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Investigating the genetic association between ERAP1 and ankylosing spondylitis [PDF]
Human Molecular Genetics, 2009 A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene.
Harvey, David +10 more
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Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]
, 2013 BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D +5 more
core +2 more sources
ERAP1 in ankylosing spondylitis
Current Opinion in Rheumatology, 2013 Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex class I molecules. Natural ERAP1 polymorphism resulting in altered enzymatic activity is associated with ankylosing spondylitis, an inflammatory disorder ...
Álvarez-Navarro, Carlos +1 more
openaire +3 more sources