Results 61 to 70 of about 6,026 (227)

Strucutral Characterization of ER aminopeptidase, ERAP1

The FASEB Journal, 2006
The endoplasmic reticulum (ER) aminopeptidase, ERAP1, is a 941 amino acid member of the M1 family of zinc metalloaminopeptidases. Unlike other aminopeptidases, ERAP1 exhibits a substrate length preference and a C‐terminal residue preference. ERAP1 has been suggested to have a molecular ruler mechanism because it trims peptides to lengths (8 or 9 amino ...
Tina T Nguyen, Lawrence J Stern
openaire   +1 more source

AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population [PDF]

, 2018
Background BehcEet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-B∗51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes)
Angioni, Mm, Carcassi, C, Cauli, A, Erre, Gl, Fiorillo, Mt, Floris, A, Lai, S, Mathieu, A., Paladini, F, Passiu, G, Piga, M, Sorrentino, R   +11 more
core   +3 more sources

Association of ERAP1 and IL23R gene polymorphisms with ankylosing spondylitis

Современная ревматология, 2020
Currently, the causes of extra-axial and extra-skeletal manifestations of ankylosing spondylitis (AS) and the possible impact of genetic aspects on its course and clinical features remain unresolved.Objective: to investigate the association of the ...
U. A. Yakubova, O. V. Bugrova, K. A. Nagornova   +2 more
doaj   +1 more source

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

PLoS ONE, 2012
The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune disorder, Crohn's disease (CD). We analysed rs30187 in
F. R. Guerini, R. Cagliani, D. Forni, C. Agliardi, D. Caputo, A. Cassinotti, D. Galimberti, C. Fenoglio, M. Biasin, R. Asselta, E. Scarpini, G.P. Comi, N. Bresolin, M.S. Clerici, M. Sironi   +14 more
openaire   +6 more sources

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia

Frontiers in Immunology, 2020
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry, Eun D. Lee, Eun D. Lee   +7 more
doaj   +1 more source

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure

Frontiers in Immunology, 2021
The mother’s uterine immune system is dominated by uterine natural killer (NK) cells during the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors (KIRs) of inhibitory or activating function. Invading extravillous
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Andrzej Malinowski, Izabela Nowak   +9 more
doaj   +1 more source

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

PLoS ONE, 2008
BackgroundEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Irini Evnouchidou, Frank Momburg, Athanasios Papakyriakou, Angeliki Chroni, Leondios Leondiadis, Shih-Chung Chang, Alfred L Goldberg, Efstratios Stratikos   +7 more
doaj   +1 more source

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

ERAP1: a potential therapeutic target for a myriad of diseases

Expert Opinion on Therapeutic Targets, 2020
Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells and NK cells. Studies have highlighted the essential requirement for the generation of stable peptide MHC I in regulating both innate and adaptive immune responses
Emma, Reeves, Yasmin, Islam, Edward, James   +2 more
openaire   +3 more sources

Cell-Specific, Disease-Associated and Variant-Linked Alterations In Expression Of ERAP1, ERAP2 and LNPEP Aminopeptidases.

Journal of Investigative Dermatology, 2023
ERAP1, ERAP2 and LNPEP are aminopeptidases implicated in autoimmune pathophysiology. Here, we demonstrate that ERAP2 is upregulated and ERAP1 is downregulated in patients with psoriasis who are homozygous for autoimmune-linked variants of ERAP.
A. Marusina, A. Ji-Xu, S. Le, A. Toussi, L. Tsoi, Qinyuan Li, G. Luxardi, J. Nava, L. Downing, A. R. Leal, N. Kuzminykh, Olga Kruglinskaya, M. Brüggen, I. Adamopoulos, A. Merleev, J. Gudjonsson, E. Maverakis   +16 more
semanticscholar   +1 more source