Results 71 to 80 of about 6,026 (227)
Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization [PDF]
, 2012 Introduction: In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities.
Apel, Maria +6 more
core +2 more sources
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
SLAS Discovery, 2023 MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment.
Leonie Müller +11 more
doaj +1 more source
Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design [PDF]
, 2014 The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells.
Boucau, Julie +4 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao +13 more
wiley +1 more source
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
Nature Communications, 2019 ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP ...
Francesca Bufalieri +26 more
doaj +1 more source
Targeting inflammatory pathways in axial spondyloarthritis. [PDF]
, 2019 The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
core
BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies [PDF]
, 2012 Genome-wide association studies (GWAS) have discovered many loci associated with common disease and quantitative traits. However, most GWAS have not studied the gene–gene interactions (epistasis) that could be important in complex trait genetics. A major
A. Gyenesei +18 more
core +2 more sources
Association of ERAP1 Allelic Variants with Risk of Ankylosing Spondylitis
Acta Naturae, 2010 Ankylosing spondylitis (AS) belongs to a group of autoimmune diseases affecting the axial skeleton. Beside thehla-b*27allele, several other human genes that control the variety processes of immune homeostasis are considered to be associated with AS manifestation in different human populations.
Zvyagin, I. +6 more
openaire +3 more sources