Results 81 to 90 of about 6,026 (227)

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The immune system performs surveillance to identify infected or cancerous cells through recognition of small protein fragments called antigenic peptides on their surface. To do this, the peptides must be cut to a specific length by an enzyme called endoplasmic reticulum aminopeptidase 1 (ERAP1).
Reeves, Emma, Colebatch-Bourn, Alexandra, Elliott, Tim, Edwards, Christopher J., James, Edward   +4 more
openaire   +3 more sources

Lnc‐CHRM4‐2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu, Jie Zang, Lili Zhang, Zhuojian Qu, Haibo Li, Chunjuan Yang, Jiamei Sun, Linlin Gai, Xuecheng Sun, Donghua Xu, Poorani Gurumallesh   +10 more
wiley   +1 more source

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Frontiers in Immunology, 2022
The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino   +5 more
doaj   +1 more source

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes

International Journal of Molecular Sciences, 2023
The human leukocyte antigen (HLA)-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disorder affecting the axial and peripheral joints, yet some HLA-B*27 variants not associated with AS have been shown.
Valentina Tedeschi, Giorgia Paldino, Josephine Alba, Emanuele Molteni, F. Paladini, R. Scrivo, M. Congia, A. Cauli, R. Caccavale, M. Paroli, Manuela Di Franco, L. Tuosto, Rosa Sorrentino, M. D’Abramo, M. Fiorillo   +14 more
semanticscholar   +1 more source

Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis [PDF]

, 2018
Background. Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non-classical MHC class I molecules that specifically interact with the natural killer receptors NKG2A ...
Angioni, Mm, Cauli, A, Congia, M, Dessole, G, Fiorillo, Mt, Floris, A, Mascia, E, Mathieu, A., Paladini, F, Piga, M, Pinna, S, Sorrentino, R, Tedeschi, V   +12 more
core   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia [PDF]

, 2009
Ankylosing spondylitis (AS) is a severe, chronic inflammatory disease strongly associated with HLA-B27. The presence of additional HLA risk factors has been suggested by several studies.
Fabiana Paladini, Francesca Belfiore, Elisa Cocco, Carlo Carcassi, Alberto Cauli, Alessandra Vacca, Maria Fiorillo, Alessandro Mathieu, Isabella Cascino, Rosa Sorrentino   +9 more
core   +2 more sources

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

International Journal of Genomics, 2018
Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic–epidemiological data are available on genetic variation within ERAP and hypertension
Robert Y. L. Zee, Alicia Rivera, Yaritza Inostroza, Paul M. Ridker, Daniel I. Chasman, Jose R. Romero   +5 more
doaj   +1 more source

Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese

Frontiers in Genetics, 2020
Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Shuqiong Zhang, Shuyuan Liu, Nannan Liu, Chuanyin Li, Chuanyin Li, Hui Wang, Lei Shi, Xinwen Zhang, Xinwen Zhang, Ling Bao, Yufeng Yao, Yufeng Yao, Li Shi   +12 more
doaj   +1 more source