Results 81 to 90 of about 95,906 (268)
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. [PDF]
, 2007 Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy.
Bose, Ron +5 more
core +1 more source
Cancer Communications, EarlyView.Abstract Background Brain metastasis, a leading cause of death in patients with lung adenocarcinoma (LUAD), arises from tumor cells adapting to the unique microenvironment of the brain through metabolic remodeling regulated by key oncogenes. Here, we aimed to determine the role of high mobility group protein box 3 (HMGB3) in regulating tumor cell ...
Huanhuan Cui +12 more
wiley +1 more source
Food Frontiers, EarlyView.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2011 Maspin is a unique member of the serpin family involved in regulation of cell migration, apoptosis and angiogenesis in breast and prostate cancers. In this study maspin expression in comparison with c-erbB-2 (HER2/neu) oncogene expression and microvessel
Izabela Berdowska +2 more
doaj +1 more source
In Vitro and in vivo anti-tumoral effects of the flavonoid apigenin in malignant mesothelioma [PDF]
, 2017 Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients' survival is poor. The polyphenol 4',5,7,-trihydroxyflavone Apigenin (API) is a "multifunctional drug". Several studies have demonstrated API anti-tumoral effects.
Andrea Modesti +13 more
core +2 more sources
Insider Influence on ErbB Activity [PDF]
Cell, 2010 The receptor tyrosine kinase ErbB is activated by ligand-induced dimerization, leading to transphosphorylation of the cytoplasmic kinase domains. Bill et al. (2010) now demonstrate that transphosphorylation can be modulated from within the cell by the cytoplasmic protein cytohesin, providing new insights into ErbB-dependent processes during normal ...
openaire +2 more sources
Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma
International Journal of Cancer, EarlyView.What's New? The progression of lung cancer from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IA) is a complex process involving molecular and microenvironment changes. Key molecular events that drive the invasion process, however, remain poorly characterized. In this comparison of gene profiles and differentially mutated genes in
Biqin Mou +19 more
wiley +1 more source
Afatinib use in recurrent epithelial ovarian carcinoma. [PDF]
, 2019 •Genomic tumor testing is an important tool in guiding treatment for gynecologic malignancies.•Targetable mutations may lead to new therapies in gynecologic cancer treatment.•Her2/neu mutations in serous ovarian carcinomas can be targeted with ERBB2 ...
Alvarez, Edwin A +3 more
core +1 more source
Novel Biomolecule‐Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury
The Laryngoscope, EarlyView.Biomolecule‐infused gelatin shows promising nerve regeneration, attenuation of muscle atrophy, and functional electromyography outcomes after recurrent laryngeal nerve injury. This biomolecule cocktail may serve as a possible long‐term treatment for vocal fold paralysis and warrants further research in additional animal models.
Ananya Tadikonda +9 more
wiley +1 more source