Results 121 to 130 of about 38,315 (266)

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, Volume 8, Issue 4, April 2025.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Molecular Systems Biology, 2009
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger   +6 more
doaj   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses

Molecular Systems Biology, 2007
Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes ...
Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek, Boris N Kholodenko   +5 more
doaj   +1 more source

Enhanced antiproliferative and apoptotic response to combined treatment of γ-tocotrienol with erlotinib or gefitinib in mammary tumor cells

BMC Cancer, 2010
Background Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated with suppression in ErbB receptor ...
Sylvester Paul W, Wali Vikram B, Bachawal Sunitha V   +2 more
doaj   +1 more source

Integrative Multi‐Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN‐2, a Covalent FGFR Inhibitor

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Using integrative multi‐omics analyses, this study maps FIIN‐2's targets and signaling networks in liver cancer cells, and identifies covalent AMPKα1 binding as a novel autophagy‐activating mechanism. The findings resolve both on‐target FGFR inhibition and off‐target protein engagement, providing a molecular roadmap to refine covalent kinase inhibitors
Ying Fu, Dandan Zhu, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Shuhong Zhang, Guangyu Xu, Zhuchu Chen, Maoyu Li, Yongheng Chen   +9 more
wiley   +1 more source

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. [PDF]

, 1994
R Ben-Levy, Hugh F. Paterson, Chris Marshall, Yosef Yarden   +3 more
openalex   +1 more source

Hybrid Electro‐optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System

Advanced Science, Volume 12, Issue 13, April 3, 2025.
A device is developed that allows simultaneous electrical and optical stimulations. The stimulator modulates AQP4 polarization, which is essential for enhancing glymphatic clearance, thus improving brain recovery from ischemic damage and reducing neurological, motor, and cognitive deficits.
Min Jae Kim, Jiman Youn, Hong Ju Lee, Seo‐Yeon Lee, Tae‐Gyu Kim, Young‐Jin Jung, Yong‐Il Shin, Byung Tae Choi, Joonsoo Jeong, Hwa Kyoung Shin   +9 more
wiley   +1 more source

Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential. [PDF]

, 1990
Hui‐Kuo G. Shu, Robert Pelley, H J Kung   +2 more
openalex   +1 more source

Antiserum raised against a synthetic phosphotyrosine-containing peptide selectively recognizes p185neu/erbB-2 and the epidermal growth factor receptor. [PDF]

, 1992
Lakshmi Bangalore, Allison Tanner, Andrew P. Laudano, David F. Stern   +3 more
openalex   +1 more source