Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities
Advanced Science, Volume 12, Issue 46, December 11, 2025.The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim +12 more
wiley +1 more source
An ultrasensitive sorting mechanism for EGF receptor endocytosis [PDF]
, 2008 Background The EGF receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling ...
Dikic, Ivan +4 more
core +2 more sources
Brazilian Journal of Medical and Biological Research, 2001 There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival ...
M. Mourão Netto +4 more
doaj +1 more source
ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury [PDF]
, 2019 Katalin Bartus +5 more
openalex +1 more source
Prognostic Implications of SMARCA4, ARID1A, and Other BAF Mutations in Non‐Small Cell Lung Cancer
Cancer Medicine, Volume 14, Issue 24, December 2025.ABSTRACT Background and Methods Non‐small cell lung cancer (NSCLC) outcomes have improved remarkably with the widespread use of immune checkpoint inhibitors and small molecule inhibitors targeting driver mutations. Nevertheless, many patients continue to experience suboptimal outcomes. The prevalence of mutations in the BAF (BRG1/BRM‐associated factor)
Alexis Khalil +2 more
wiley +1 more source
Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor [PDF]
, 2012 The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
core +1 more source
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes [PDF]
, 2002 Jeannine M. Mendrola +3 more
openalex +1 more source
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Introduction Gliomas remain aggressive despite current therapies, highlighting the urgent need for new biomarkers and targets. Transmembrane protein 106A (TMEM106A), implicated as a tumor suppressor in various cancers, has an unclear role in gliomas. We hypothesized that TMEM106A expression associates with tumor aggressiveness and may serve as
Wen‐Shin Song +3 more
wiley +1 more source
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
Biomarker Insights, 2015 Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj +1 more source