DETECTION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND C-ERBB-2 GENE AMPLIFICATION IN TRANSITIONAL-CELL BLADDER-CARCINOMA USING THE DIFFERENTIAL PCR TECHNIQUE [PDF]
, 1994 Vassilis G. Gorgoulis +3 more
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Plasma circulating microRNAs and symptoms of depression: Results from a population‐based study
Psychiatry and Clinical Neurosciences, EarlyView.Background Depression is a complex mental disorder with a multifactorial etiology. Recent research has highlighted the potential of microRNAs (miRNAs) as novel biomarkers and their involvement in the molecular pathways underlying depression; yet, these studies often focus on limited clinical samples and specific subsets of miRNAs.
Midas M. Kuilman +6 more
wiley +1 more source
Experimental Physiology, EarlyView.ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler +12 more
wiley +1 more source
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. [PDF]
, 1994 R Ben-Levy +3 more
openalex +1 more source
Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury
The Journal of Physiology, EarlyView.Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen +6 more
wiley +1 more source
Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential. [PDF]
, 1990 Hui‐Kuo G. Shu +2 more
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Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor [PDF]
, 2012 The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
core +1 more source
CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 387-409, September/October 2025.Abstract The discovery of activating mutations in the epidermal growth factor receptor (EGFR) gene has revolutionized the management of lung cancer, enabling the development of targeted tyrosine kinase inhibitors (TKIs). These therapies offer improved survival and reduced side effects compared with conventional treatments.
Maxime Borgeaud +9 more
wiley +1 more source
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers [PDF]
, 1998 Anne E.G. Lenferink
openalex +1 more source
Advanced Science, Volume 12, Issue 33, September 4, 2025.Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu +5 more
wiley +1 more source