Results 151 to 160 of about 33,653 (199)

ErbB-4: a receptor tyrosine kinase

Inflammation Research, 2002
ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events.
W, Zhou, G, Carpenter
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ErbB receptors and signaling pathways in cancer

Current Opinion in Cell Biology, 2009
The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer development and progression.
Nancy E, Hynes, Gwen, MacDonald
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The EGF/ErbB Receptor Family and Apoptosis

Growth Factors, 2002
The ErbB receptor family can activate a multitude of cell signaling pathways that involve many aspects of cellular function. The four members of the ErbB receptor family interact with diverse ligands and substrates, as well as with each other through cell surface heterodimerization.
Andrew J, Danielsen, Nita J, Maihle
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ErbB Receptors and Cancer

2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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Targeting ErbB receptor signaling: A pan-ErbB approach to cancer

Molecular Cancer Therapeutics, 2004
Abstract The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential.
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Targeting ErbB Receptors in High-Grade Glioma

Current Pharmaceutical Design, 2011
High-grade gliomas, including glioblastoma, are among the most malignant and treatment-refractory human neoplasms. The tumors show high levels of resistance to conventional therapies (i.e. surgery, irradiation, and chemotherapy), and despite treatment advances patient outcome remains poor. New therapeutic options are needed.
Sabina, Berezowska, Jürgen, Schlegel
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Neu/ErbB-2 Receptor

1995
Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
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Androgen receptor versus erbB-1 and erbB-2 expression in human prostate neoplasms

Oncology Reports, 2004
A subject of current interest, especially in the development of androgen refractory prostate cancer, is the androgen receptor (AR) activation by growth factor receptors. Here, we report our work on the measurement of AR mRNA and protein expression in benign prostatic hyperplasia (BPH) and prostatic carcinoma (PCA) and evaluation of the relationship ...
Magdalena, Brys, Magdalena, Stawinska, Marek, Foksinski, Andrzej, Barecki, Cezary, Zydek, Eugeniusz, Miekos, Wanda M, Krajewska   +6 more
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EGF/ErbB Receptor Family in Ovarian Cancer

2002
In summary, the EGF/ErbB family of receptor tyrosine kinases has been shown to play a key role in normal ovarian follicle development, and cell growth regulation of the ovarian surface epithelium. Disregulation of these normal growth regulatory pathways, including overexpression and/or mutation of EGFR/ErbB receptor family members, as well as elements ...
N J, Maihle, A T, Baron, B A, Barrette, C H, Boardman, T A, Christensen, E M, Cora, J M, Faupel-Badger, T, Greenwood, S C, Juneja, J M, Lafky, H, Lee, J L, Reiter, K C, Podratz   +12 more
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