Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity [PDF]
Journal of Biological Chemistry, 2004 Four ErbB receptors and multiple growth factors sharing an epidermal growth factor (EGF) motif underlie transmembrane signaling by the ErbB family in development and cancer. Unlike other ErbB proteins, ErbB-2 binds no known EGF-like ligand.
Bose Kochupurakkal +15 more
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Structure-function analysis of nucleolin and ErbB receptors interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB receptor tyrosine kinases and nucleolin are major contributors to malignant transformation. Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail.
Keren Farin +3 more
doaj +2 more sources
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells. [PDF]
Sci Rep, 2017 Momeny M +21 more
europepmc +3 more sources
Targeting erbB receptors. [PDF]
Semin Cell Dev Biol, 2010 Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Cai Z +6 more
europepmc +5 more sources
ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors
Nature Reviews Cancer, 2005 ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
N. Hynes, H. Lane
semanticscholar +5 more sources
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Molecules and Cells, 2003 Antony W. Burgess +9 more
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Progress in the Research and Targeted Therapy of ErbB/HER Receptors in Urothelial Bladder Cancer
Frontiers in Molecular Biosciences, 2021 Bladder cancer is a lethal malignancy and a majority of bladder cancer arise from urothelial cells. Infiltration and metastasis are barriers for the radical cystectomy to achieve favored outcome and are the main cause of death.
Dong Chen +3 more
doaj +1 more source
The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Epigenomes, 2023 Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos +6 more
doaj +1 more source
Identification of nucleolin as new ErbB receptors- interacting protein. [PDF]
PLoS ONE, 2008 BACKGROUND: The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
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Translocation of ErbB receptors into the nucleus [PDF]
Revista de Oncología, 2003 The work in the authors laboratory was financed by grants (to AV) from the Comisión Interministerial de Ciencia y Tecnología (SAF2002-03258), the Consejería de Educación de la Comunidad de Madrid (08.1/0027/2001-1), and the Agencia Española de Cooperación Internacional (2002CN0013).
Villalobo, Antonio +2 more
openaire +2 more sources