Results 21 to 30 of about 38,315 (266)
ERBB receptors in cancer: signaling from the inside. [PDF]
Breast Cancer Res, 2011 ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family.
Arteaga CL.
europepmc +5 more sources
Biomolecules, 2023 Epidermal growth factor (EGF) and its homologs, such as neuregulins, bind to ErbB (Her) receptor kinases and regulate glial differentiation and dopaminergic/GABAergic maturation in the brain and are therefore implicated in schizophrenia neuropathology ...
Hidekazu Sotoyama +3 more
doaj +1 more source
ErbB polymorphisms: Insights and implications for response to targeted cancer therapeutics
Frontiers in Genetics, 2015 Advances in high-throughput genomic-scanning have expanded the repertory of genetic variations in DNA sequences encoding ErbB tyrosine kinase receptors in humans, including single nucleotide polymorphisms (SNPs), polymorphic repetitive elements ...
Moulay A Alaoui-Jamali +2 more
doaj +1 more source
ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS [PDF]
Biotechnologia Acta, 2013 History of developing synergy between monoclonal antibodies, anti-tumor activity of monoclonal antibodies against tyrosine-kinases receptors EGFR/ErbB-1 and HER2/ErbB-2 as well as growth factor VEGF in various combinations are considered in the article ...
Michael Sela
doaj +1 more source
Thoracic Cancer, Volume 13, Issue 24, Page 3441-3450, December 2022., 2022 Breast cancer with concurrent TP53 mutation and MYC amplification demonstrated higher grade and stage, more positive HER2 status, higher Ki67 levels, and more mutations in genes involved in ERBB and TGF‐β signaling pathways, as well as exclusive FANCG/CDKN2B/QKI copy number amplifications.
Xiaoyi Lin +4 more
wiley +1 more source
Biomolecules, 2022 The cross-talk between axon and glial cells during development and in adulthood is mediated by several molecules. Among them are neurotransmitters and their receptors, which are involved in the control of myelinating and non-myelinating glial cell ...
Roberta Piovesana +5 more
doaj +1 more source
The ErbB receptor tyrosine family as signal integrators. [PDF]
Endocrine-related cancer, 2001 ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancement of ligand-induced biological responses.
Nancy E. Hynes +3 more
openalex +4 more sources
Thoracic Cancer, Volume 14, Issue 2, Page 156-167, January 2023., 2023 Circulating tumor cells (CTCs) were clustered into two subtypes significantly correlated with the lymph node metastasis status of early breast cancer patients. Patients with lymph node metastasis have CTCs that express an epithelial/stem‐like pattern of metastasis initiating cells, while those patients without lymph node metastasis have CTCs that have ...
Shuyun Pang +9 more
wiley +1 more source
PLoS ONE, 2011 BackgroundBetacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells.
Yoon Sin Oh +4 more
doaj +1 more source
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source