The ErbB receptor tyrosine family as signal integrators. [PDF]
Endocrine-related cancer, 2001 ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancement of ligand-induced biological responses.
Nancy E. Hynes +3 more
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ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. [PDF]
Cancer Cell, 2014 Arteaga CL, Engelman JA.
europepmc +2 more sources
ErbB receptors in the biology and pathology of the aerodigestive tract. [PDF]
Exp Cell Res, 2009 The most common sites of malignancies in the aerodigestive tract include the lung, head and neck and the esophagus. Esophageal adenocarcinomas (EA), esophageal squamous cell carcinomas (ESCC), and squamous cell carcinomas of the head and neck (SCCHN) are the primary focus of this review.
Morgan S, Grandis JR.
europepmc +5 more sources
The spatiotemporal organization of ErbB receptors: insights from microscopy. [PDF]
Cold Spring Harb Perspect Biol, 2014 Valley CC, Lidke KA, Lidke DS.
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Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity [PDF]
Journal of Biological Chemistry, 2004 Four ErbB receptors and multiple growth factors sharing an epidermal growth factor (EGF) motif underlie transmembrane signaling by the ErbB family in development and cancer. Unlike other ErbB proteins, ErbB-2 binds no known EGF-like ligand.
Bose Kochupurakkal +15 more
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Structure-function analysis of nucleolin and ErbB receptors interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB receptor tyrosine kinases and nucleolin are major contributors to malignant transformation. Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail.
Keren Farin +3 more
doaj +2 more sources
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells. [PDF]
Sci Rep, 2017 Momeny M +21 more
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An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Molecules and Cells, 2003 Antony W. Burgess +9 more
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Progress in the Research and Targeted Therapy of ErbB/HER Receptors in Urothelial Bladder Cancer
Frontiers in Molecular Biosciences, 2021 Bladder cancer is a lethal malignancy and a majority of bladder cancer arise from urothelial cells. Infiltration and metastasis are barriers for the radical cystectomy to achieve favored outcome and are the main cause of death.
Dong Chen +3 more
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Identification of nucleolin as new ErbB receptors- interacting protein. [PDF]
PLoS ONE, 2008 BACKGROUND: The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
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