Results 21 to 30 of about 33,653 (199)

Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]

PLoS ONE, 2010
The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira, Takunori Satoh, Donna M Fekete, Lisa V Goodrich   +3 more
doaj   +1 more source

Ligand-induced ErbB receptor dimerization [PDF]

Experimental Cell Research, 2009
Structural studies have provided important new insights into how ligand binding promotes homodimerization and activation of the EGF receptor and the other members of the ErbB family of receptor tyrosine kinases. These structures have also suggested possible explanations for the unique properties of ErbB2, which has no known ligand and can cause cell ...
openaire   +2 more sources

Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

BMC Evolutionary Biology, 2006
Background In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data
Staros James V, Stein Richard A
doaj   +1 more source

Targeting the Calmodulin-Regulated ErbB/Grb7 Signaling Axis in Cancer Therapy

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will
Antonio Villalobo, Irene García-Palmero, Silviya R. Stateva, Karim Jellali   +3 more
doaj   +1 more source

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis [PDF]

FEBS Letters, 2015
The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis.
Dahlhoff, Maik, Camera, Emanuela, Ludovici, Matteo, Picardo, Mauro, Müller, Udo, Leonhardt, Heinrich, Zouboulis, Christos C., Schneider, Marlon R.   +7 more
openaire   +2 more sources

Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas.

PLoS ONE, 2008
BackgroundTamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase in ...
Valentina Folgiero, Paolo Avetrani, Giulia Bon, Selene E Di Carlo, Alessandra Fabi, Cecilia Nisticò, Patrizia Vici, Elisa Melucci, Simonetta Buglioni, Letizia Perracchio, Isabella Sperduti, Laura Rosanò, Ada Sacchi, Marcella Mottolese, Rita Falcioni   +14 more
doaj   +1 more source

The Dumb ErbB Receptor Helps Healing [PDF]

Journal of Investigative Dermatology, 2007
ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.
openaire   +3 more sources

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]

Oncogene, 1997
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
T, Komurasaki, H, Toyoda, D, Uchida, S, Morimoto   +3 more
openaire   +2 more sources

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

PLoS ONE, 2012
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause, Kin K Leung, John L Barkinge, Mark F Ciaccio, Chih-Pin Chuu, Richard B Jones   +5 more
doaj   +1 more source