Results 61 to 70 of about 33,653 (199)
Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor. [PDF]
PLoS ONE, 2015 Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members, namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular dysfunction.
Saghir Akhtar +5 more
doaj +1 more source
Interaction of antibodies with ErbB receptor extracellular regions [PDF]
Experimental Cell Research, 2009 Antibodies to the extracellular region of the ErbB receptors have played key roles in the development of a mechanistic understanding of this family of receptor tyrosine kinases. An extensively studied class of such antibodies inhibits activation of ErbB receptors, and these antibodies have been the focus of intense development as anti-cancer agents. In
Karl R, Schmitz, Kathryn M, Ferguson
openaire +2 more sources
Gastric signet‐ring cell carcinoma in a child: A clinical case study
JPGN Reports, EarlyView.Abstract Gastric signet‐ring cell carcinoma (SRCC) is a rare form of gastric cancer characterized by mucus‐rich tumor cells forming a distinctive ring‐like appearance and is exceedingly rare in children, accounting for less than 1% of all childhood malignancies.
Jiaxian Wang +6 more
wiley +1 more source
ChemistryOpen, EarlyView.New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha +6 more
wiley +1 more source
Pediatric Discovery, EarlyView.ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang +4 more
wiley +1 more source
BMC Cancer, 2012 Background Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases.
Hiscox Stephen +9 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Cancer Science, EarlyView.Using a machine learning–based approach in a multi‐institutional prospective cohort, we identified a robust miRNA signature that demonstrated high diagnostic accuracy for esophageal squamous cell carcinoma. Our 57‐miRNA panel achieved an AUC of 0.90 in the proof‐of‐concept cohort and 0.85 in an independent validation cohort, with a sensitivity of 84 ...
Tatsuro Murano +14 more
wiley +1 more source
Drug Design, Development and Therapy, 2018 Dehua Liao,1,2 Yujin Guo,3 Daxiong Xiang,2 Ruili Dang,3 Pengfei Xu,3 Hualin Cai,2 Lizhi Cao,1 Pei Jiang3 1Department of Pharmacy, Hunan Cancer Hospital, 2Department of Pharmacy, Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital,
Liao D +7 more
doaj
Increased activation of ErbB and NF-κB signalling pathways in Darier disease affected skin. [PDF]
J Eur Acad Dermatol VenereolJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 506-509, March 2026.
Ernst N, Ludwig RJ, Vorobyev A.
europepmc +2 more sources