Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis.
PLoS ONE, 2021 Increasing reports of azole resistance in Candida tropicalis, highlight the development of rapid resistance detection techniques. Nonsynonymous mutations in the lanosterol C14 alpha-demethylase (ERG11) gene is one of the predominant mechanisms of azole ...
Saikat Paul +6 more
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Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression [PDF]
Antimicrobial Resistance and Infection Control, 2021 Background Candida tropicalis (C. tropicalis) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C.
Dan Wang +5 more
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An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.
PLoS ONE, 2020 Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil +4 more
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Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility [PDF]
Microbiology SpectrumMalassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment.
Cheryl Leong +6 more
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Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa [PDF]
Genetics and Molecular Biology, 2014 The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil.
Geruza de Oliveira Ceita +10 more
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All LifeIntroduction Candida albicans is an opportunistic pathogen linked to severe, often fatal, infections. Azoles are the first line of treatment, but its resistance has increasingly been reported worldwide.
Elisa María Sánchez-Villacreses +5 more
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Dual inhibition of ERG11 and CDR2 in drug-resistant Candida albicans by Indian phytochemicals: a combined in silico–in vitro approach [PDF]
Frontiers in PharmacologyInvasive candidiasis caused by drug-resistant Candida albicans is an escalating global health concern due to the declining efficacy of conventional antifungal therapies.
Akshay Kisan Mundhe, Reena Rajkumari
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Fluconazole resistance among Candida species with special emphasis on ERG11 gene mutations among Candida tropicalis [PDF]
Frontiers in Fungal BiologyIntroductionCandidiasis, an opportunistic fungal infection, is increasingly caused by non-albicans Candida species that show reduced fluconazole susceptibility, mainly due to ERG11 overexpression.
Vidyavathi B. Chitharagi +5 more
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Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]
PLoS ONE, 2015 To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He +13 more
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Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities [PDF]
Nature CommunicationsAzole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11
Wanqian Li +5 more
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