Results 11 to 20 of about 6,538 (228)

Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalis [PDF]

Journal of Fungi
We investigated the molecular mechanisms underlying azole resistance in seven Candida tropicalis isolates that caused candidemia and candiduria in Paraná, Brazil (2016–2022).
Adriele Celine Siqueira, Gisele Aparecida Bernardi, Lavinia Nery Villa Stangler Arend, Gabrielle Tomé Cordeiro, Daiane Rosolen, Fernanda Costa Brandão Berti, Amanda Maria Martins Ferreira, Thaís Muniz Vasconcelos, Bianca Cruz Neves, Luiza Souza Rodrigues, Libera Maria Dalla-Costa   +10 more
doaj   +3 more sources

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
doaj   +3 more sources

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients [PDF]

Current Medical Mycology, 2019
Background and Purpose: Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration.
Sony Paul, Iyanar Kannan, Kalyani Mohanram   +2 more
doaj   +3 more sources

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban   +9 more
doaj   +2 more sources

Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates

Current Medical Mycology, 2017
Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades.
Nasrin Parsamehr, Sasan Rezaie, Sadegh Khodavaisy, Samira Salari, Sanaz Hadizadeh, Mohammad Kord, Seyed Amin Ayatollahi Mousavi   +6 more
doaj   +3 more sources

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +3 more sources

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
doaj   +2 more sources

Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates [PDF]

Molecular Biology Reports, 2022
Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare Bidaki, Anis Maleki, Nahid Ghanbarzadeh, Fatemeh Nikoomanesh   +3 more
openalex   +3 more sources

Characterization of ERG11 Gene in Drug-Resistant Candida Albicans Isolated from Iranian Cases of Recurrent Vulvovaginal Candidiasis [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2020
Background & Aims:  Candida albicans is the most common fungal pathogen of human infections. C. albicans is responsible for significant mucosal infections such as vulvovaginitis in women.
Kambiz Diba, Shahram Khademvatan, Kowsar Jaafari, Soudabe Abharian   +3 more
doaj   +1 more source

PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11

mSphere
The widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu, Shuting Ye, Mi Zhou, Long Zhang, Zhongchi Zhang, Xianyun Sun, Shaojie Li, Chengcheng Hu   +7 more
doaj   +2 more sources