Results 21 to 30 of about 6,538 (228)

Universal PCR assays to detect Candida FKS and ERG11 mutations

International Journal of Infectious Diseases
Introduction: The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients.
Dr Yuk Yam Cheung, Mr. Zhi Hao ZHANG, Ms. Wing Yan CHAR, Mr. Tsun Hang FONG, Mr. Chun Yu LI   +4 more
doaj   +2 more sources

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata [PDF]

, 2021
AbstractAzoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal membrane sterol.
Bao Gia Vu, W. Scott Moye‐Rowley
openalex   +2 more sources

Non-albicans Candida in Vulvovaginal Candidiasis: Antifungal Resistance and Expression of ERG11, CDR1, CDR2, and MDR1 Genes. [PDF]

Microbiologyopen
The rise in azole resistance among Nakaseomyces glabratus and Pichia kudriavzevii presents a growing public health challenge. These results indicate that even in cases where an isolate is classified as susceptible by drug susceptibility testing, elevated gene expression may persist, and treatment should not be discontinued.
Ranjbar Golafshani FZ, Kermani F, Abbaszadeh Godarzi S, Mahdavi Omran S.   +3 more
europepmc   +2 more sources

ERG11 Gene Variability and Azole Susceptibility in Malassezia pachydermatis

Mycopathologia, 2022
AbstractMalassezia pachydermatis is part of the normal skin microbiota of various animal species but under certain circumstances becomes an opportunistic pathogen producing otitis and dermatitis. Commonly these Malassezia diseases are effectively treated using azoles. However, some cases of treatment failure have been reported. Alterations in the ERG11
Leyna Díaz, Gemma Castellá, M. Rosa Bragulat, F. Javier Cabañes   +3 more
openaire   +3 more sources

Candidemia in cancer patients: phenotypical and molecular-genetic characteristics of antifungal drug resistance, pathogenic factor genes of Candida spp.

Сибирский онкологический журнал, 2022
Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova, E. A. Goremykina, P. V. Slukin, O. E. Khokhlova, N. K. Fursova, I. N. Petukhova, Z. V. Grigorievskaya   +6 more
doaj   +1 more source

Inter-Hospital Spread of Fluconazole-Resistant C. parapsilosis in Northern Italy: Insights Into Clonal Distribution, Resistance Mechanisms and Biofilm Production. [PDF]

Mycoses
ABSTRACT Background Starting from 2018 onwards, several outbreaks of fluconazole‐resistant C. parapsilosis have been reported in many countries worldwide. Objectives Here we report a retrospective study on C. parapsilosis blood isolates collected over 7 years (2018–2024) in two hospitals in Northern Italy.
Palladini G, Lepera V, Trubini S, Tocci G, Zappavigna A, Iskandar E, Ferrari G, Prigitano A, Ferraro N, Schiavo R, Baldanti F, Cavanna C, Lo Cascio G.   +12 more
europepmc   +2 more sources

Spectrum and functional properties of ERG11 gene mutations in fluconazole-resistant Candida albicans strains isolated from HIV-infected patients

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva   +7 more
doaj   +1 more source

Oral microbiota in patients with oropharyngeal cancer with an emphasis on Candida spp.

Опухоли головы и шеи, 2022
Introduction. Interactions between the 2 microbiota components – bacteria and fungi – are of interest as diagnostic and prognostic markers in selection of treatment tactics for oncological patients.Aim.
N. S. Bagirova, I. N. Petukhova, Z. V. Grigorievskaya, A. V. Sytov, P. V. Slukin, E. A. Goremykina, O.  E. Khokhlova, N.  K. Fursova, A. E.  Kazimov   +8 more
doaj   +1 more source

CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow

Инфекция и иммунитет, 2022
Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing ...
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu. V. Nesvizhsky, E. A. Voropaeva, E. I. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev   +8 more
doaj   +1 more source

The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows

Frontiers in Veterinary Science, 2021
Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du, Jun Du, Wenshuang Ma, Wenshuang Ma, Jiaqi Fan, Jiaqi Fan, Xiaoming Liu, Xiaoming Liu, Yujiong Wang, Yujiong Wang, Xuezhang Zhou, Xuezhang Zhou   +11 more
doaj   +1 more source