Molecular Identification and Evaluation of Resistance to Antifungal Drugs in Candida Species Isolated From Diaper Rash of Neonates [PDF]
Health Sci RepABSTRACT Background Diaper dermatitis, also recognized as diaper rash, is one of the most frequent skin conditions in neonates. Materials and Methods A total of 100 babies participated in the study. Eligibility included neonates aged 5–28 days and full‐time diaper wearers.
Shirvani F +14 more
europepmc +2 more sources
Antimicrobial Agents and Chemotherapy, 2020 Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated.
Patricia Navarro-Rodríguez +4 more
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Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis [PDF]
Iranian Biomedical Journal, 2017 Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined.
Ensieh Lotfali +7 more
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ERG11 couples oxidative stress adaptation, hyphal elongation and virulence in Candida albicans [PDF]
FEMS Yeast Research, 2018 Candida albicans is a major fungal opportunistic pathogen for humans. In the treatment of C. albicans, azole drugs target the sterol 14α-demethylase (CYP51) encoded by ERG11 gene. Most studies have focused on the fact that the ERG11 mutant results in drug resistance, but its mechanism of action as a drug target has not been described yet.
YongQin, Wu +5 more
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Candida tropicalis distribution and drug resistance correlated to ERG11 and UPC2 expression [PDF]
, 2020 Abstract Objective: This study is to analyze the distribution characteristics and drug resistance of Candida tropicalis, and the relationship between ERG11 and UPC2 expression and the resistance to azole.Methods: The Candida tropicalis were cultured and identified by the Sabouraud Agar Medium, CHROM Agar Candida and France Bio-Mérieux ATB test.
Dan Wang +5 more
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Di-san junyi daxue xuebao, 2020 Objective To screen the genes associated with fluconazole resistance in Trichosporon asahii to facilitate mechanistic studies of fluconazole resistance and the development of new antifungal agents. Methods Three clinical isolates of fluconazole-sensitive
XIA Zhikuan1 +6 more
doaj +1 more source
Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]
, 2014 BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M. +3 more
core +1 more source
Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion [PDF]
Antimicrobial Agents and Chemotherapy, 1996 The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase.
V L, Kan, A, Geber, J E, Bennett
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Emergence of Candida (Candidozyma) auris in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses [PDF]
MycosesABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Tomé L +19 more
europepmc +2 more sources
The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. [PDF]
, 2015 The transition between a unicellular yeast form to multicellular filaments is crucial for budding yeast foraging and the pathogenesis of many fungal pathogens such as Candida albicans.
Höfken, T, Woods, K
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