Results 41 to 50 of about 6,538 (228)

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso

BMC Infectious Diseases, 2022
Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased.
Essi Etonam Dovo, Théodora Mahoukèdè Zohoncon, Sessi Frida Tovo, Serge Théophile Soubeiga, Isabelle Touwendpoulimdé Kiendrebeogo, Albert Théophane Yonli, Rogomenona Alice Ouedraogo, Amana Mètuor Dabire, Florencia Wendkuuni Djigma, Christelle Wendyam Nadembega, Marius Belemgnegre, Paul Ouedraogo, Dorcas Obiri-Yeboah, Jacques Simpore   +13 more
doaj   +1 more source

Characterization ofProtothecaCYP51/ERG11 as a possible target for therapeutic drugs

Medical Mycology, 2021
AbstractPrototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis ...
Takahisa Watanabe, Tomohiro Ishikawa, Hirotaka Sato, Noriyuki Hirose, Lisa Nonaka, Kaori Matsumura, Akira Masubuchi, Kazuko Nishimura, Michiaki Masuda   +8 more
openaire   +2 more sources

Structure Prediction and Functional Characterization of ERG Proteins Involved in Ergosterol Biosynthetic Pathway of Candida albicans [PDF]

, 2011
The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and
Ashok Sharma, Suaib Luqman, Sudeep Roy   +2 more
core   +2 more sources

Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]

, 2018
We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T, Jain, Priyanka, Khan, Mohammad Firoz, Komath, Sneha Sudha, Pal, Nibedita, Pratyusha, Vavilala A, Sen, Sobhan, Sethi, Subhash Chandra, Singh, Sneh Lata, Victoria, Guiliana Soraya, Yadav, Bhawna   +10 more
core   +3 more sources

Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]

, 2017
This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba, van der Lee, Henrich, Verweij, Paul, Warris, Adilia   +3 more
core   +1 more source

Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis.

PLoS ONE, 2022
This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C.
Saikat Paul, Dipika Shaw, Himanshu Joshi, Shreya Singh, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Anup K Ghosh   +6 more
doaj   +1 more source

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]

, 2019
Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni, Bianchi, Michele Maria, Cirigliano, Angela, Macone, Alberto, Negri, Rodolfo, Oliaro-Bosso, Simonetta, Rinaldi, Teresa   +6 more
core   +2 more sources

The Risk Factors and Mechanisms of Azole Resistance of Candida tropicalis Blood Isolates in Thailand: A Retrospective Cohort Study

Journal of Fungi, 2022
In recent decades, an epidemiological shift has been observed from Candida infections to non-albicans species and resistance to azoles. We investigated the associated factors and molecular mechanisms of azole-resistant blood isolates of C.
Teera Leepattarakit, Orawan Tulyaprawat, Popchai Ngamskulrungroj   +2 more
doaj   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources

ERG11 and ABC2 Overexpression but Not ERG11 Gene Mutations Are Involved in the Development of Itraconazole Resistance in Candida Krusei

Blood, 2015
Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Juanxia Meng, Qi Deng, Tao Sui   +12 more
openaire   +1 more source