Results 51 to 60 of about 6,538 (228)

Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes [PDF]

, 2017
Traditional approaches to drug discovery are frustratingly inefficient and have several key limitations that severely constrain our capacity to rapidly identify and develop novel experimental therapeutics.
Ai, Becker, Bolstad, Bonnett, Burke, Butts, Chidley, DiMasi, Finkel, Fonzi, Gerami-Nejad, Gerami-Nejad, Gietz, Gratacap, Hitchcock, Johnston, Liu, Livak, Luna-Tapia, Markwardt, Matz, Miller, Nzila, Parker, Paulsen, Pucci, Puigbò, Ramón, Schenone, Schmitt, Shagin, Shaner, Shaner, Silver, Singh, Venkateswarlu, Wilson, Wilson, Zhang, Zhang   +39 more
core   +3 more sources

Detection of ERG11 point mutations in Iranian fluconazoleresistant Candida albicans isolates

Current Medical Mycology, 2019
Background and Purpose: Candidiasis is referred to a group of superficial anddeep-tissue fungal infections often caused by Candida albicans. The superficialinfections affect the oral, oropharynx, esophagus, and vaginal mucosa. The treatmentof choice for these infections is the use of azoles, such as fluconazole.
Ali Sardari, Hossein Zarrinfar, Rasoul Mohammadi   +2 more
openaire   +3 more sources

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
A Lupetti, A Viudes, C d'Enfert, CA Kumamoto, CJ Nobile, CJ Nobile, D Andes, D Shahinas, David Andes, E Mowat, EM Kojic, ET Burt, G Ramage, G Ramage, G Ramage, G Ramage, G Ramage, Gordon Ramage, J McCourtie, J Nett, J Trepel, JB Anderson, JC Young, JE Nett, Jeniel Nett, Jose L. Lopez-Ribot, JR Blankenship, JS Finkel, L Ostrosky-Zeichner, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, Leah E. Cowen, LH Pearl, LS Wilson, M Taipale, MA Pfaller, MA Pfaller, MJ Seidler, ML Richard, MM McNeil, Nicole Robbins, P Perumal, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, PK Mukherjee, Priya Uppuluri, R Pallavi, Ranjith Rajendran, Robin Charles May, RS Shapiro, RS Shapiro, S Garcia-Sanchez, S Park, S Perea, SD Singh, SJ Lin, SL LaFayette, SM Noble, SV Balashov, SZ Usmani, TE Zaoutis, Y Kaneko, YS Kim, Z Odabasi   +69 more
core   +9 more sources

Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda

Journal of Fungi, 2022
Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim, David B. Meya, Elliot S. Gerlach, Dennis Muhanguzi, Allan Male, Benedict Kanamwanji, Kirsten Nielsen   +6 more
doaj   +1 more source

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates

Medical Mycology, 2022
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM   Objective To determine the profile of fluconazole-resistant Candida isolates (FRCS) and the proportion of erg11 gene mutation in fluconazole-resistant C.
M.S., Sheena, Singh, Rakesh
openaire   +1 more source

Biochemical research elucidating metabolic pathways in Pneumocystis*

Parasite, 2010
Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
doaj   +1 more source

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]

, 2019
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller, Altamirano, Arechavala, Bicanic, Bicanic, Boeva, Chang, Chen, Dannaoui, DePristo, Drusano, Harrison, Li, Longley, Loyse, Martin, Mayanja-Kizza, McKenna, Molloy, Mondon, Neely, Nixon, Nussbaum, Saag, Sionov, Sionov, Stone, Stott, Stott, Sudan, Wiederhold, Witt   +31 more
core   +1 more source

Analysis of ergosterol and gene expression profiles of sterol ∆5,6-desaturase (ERG3) and lanosterol 14α-demethylase (ERG11) in Candida albicans treated with carvacrol [PDF]

, 2018
Introduction: Usually, for treatment of fungal infections, antifungals such as azoles are used, but one of the biggest problems faced in clinical practice is the emergence of resistance for most of these drugs.
Alizadeh, Fahimeh., Esfandyari, Samad., Khodavandi, Alireza., Nouripour-Sisakht, Sadegh.   +3 more
core   +2 more sources

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in Candida Species

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta, Tal Kopp, Ivan Voronov, Adi Yona, Rania Hasib Afana, Shmuel Carmeli, Micha Fridman   +6 more
wiley   +2 more sources

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]

, 2018
BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J, Bicanic, T, Fisher, MC, Harrison, TS, Hope, W, Kivuyo, S, Kwon-Chung, J, Mfinanga, S, Molloy, SF, Needleman, L, Rhodes, J, Rugemalila, J, Segal, ES, Stone, NR   +13 more
core   +6 more sources