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Mechanism of azole resistance in <i>Candida glabrata</i> isolates from India: clinical vs. induced perspectives. [PDF]

J Med Microbiol
Pawar K, Singh A.
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Investigation of mutations in Erg11 gene of fluconazole resistant Candida albicans isolates from Turkish hospitals.

Mycoses, 2011
Widespread use of fluconazole has resulted in resistance in strains of Candida. The aim of our study was to investigate Y132H and other mutations in the ERG11 gene in conferring fluconazole resistance to C. albicans isolates. Seven fluconazole-resistant (R)/susceptible dose-dependent (SDD)/trailing and 10 fluconazole-susceptible (S) isolates were ...
Ergon, MAHMUT CEM, Manastir, Lerzan, Yucesoy, Mine   +2 more
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The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen, Tan, Jinqing, Zhang, Wei, Chen, Yi, Sun, Zhe, Wan, Ruoyu, Li, Wei, Liu   +6 more
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The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance

Revista Iberoamericana de Micología, 2013
For many years fluconazole has been commonly used to treat Candida infections. However, the indiscriminate use of this antimycotic therapy has favored the emergence of resistant isolates. Mutations in the ERG11 gene have been described as one of the primary mechanisms of resistance in Candida species.In this study we investigated missense mutations in ...
Vagner, Oliveira Carvalho, Thelma S, Okay, Márcia S C, Melhem, Maria, Walderez Szeszs, Gilda M B, del Negro   +4 more
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Detection of ERG11 gene in fluconazole resistant urinary candida isolates

Egyptian journal of Immunology, 2022
Candida species resistant to fluconazole and voriconazole were screened for the presence of ERG11gene by polymerase chain reaction (PCR). Also, the association of this gene with the demonstration of Candida virulence factors; biofilm formation, phospholipase and proteinases activities were studied.
Manal, El Said, Hala, Badawi, Doaa, Gamal, Dalia, Salem, Heba, Dahroug, Amira, El-Far   +5 more
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ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates

Archives of Microbiology, 2015
Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance.
Yonghao, Xu, Fang, Sheng, Jie, Zhao, Lamei, Chen, Chunyang, Li   +4 more
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Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole

Journal of Medical Microbiology, 2021
Introduction. Trichosporon asahii has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Hypothesis/Gap Statement. Molecular mechanisms of azole resistance have been rarely reported for Trichosproron asahii.
S, Abbes, H, Sellami, S, Neji, H, Trabelsi, F, Makni, A, Ayadi   +5 more
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Cloning and characterization of the lanosterol 14α-demethylase (ERG11) gene in Cryptococcus neoformans

Biochemical and Biophysical Research Communications, 2004
The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar, J, Fu, M G, Rinaldi, S L, Kelly, D E, Kelly, D C, Lamb, S M, Keller, B L, Wickes   +7 more
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[Analysis of ERG11 gene mutation in Candida albicans].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2007
To study the relationship between fluconazole (FCZ)-resistance of Candida albicans and the mutation of ERG11 gene encoding FCZ-targeted enzyme.Three strains of FCZ-susceptible and 10 FCZ-resistent C. albicans were isolated from the urethra, vagina, oropharynx, respiratory tract, prostate secretion and blood samples.
Ying-bin, Wang, Hong, Wang, Hui-yu, Guo, Yong-zhong, Zhao, Shen-qiu, Luo   +4 more
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Fluconazole‐resistant Candida parapsilosis complex candidemia and analysis of mutations in the ERG11 gene from Pakistan

Mycoses, 2023
AbstractBackgroundRecent reports of the emergence of fluconazole resistance in Candida parapsilosis species complex poses a challenge, more specifically in settings where echinocandin‐based treatment regime is not feasible.ObjectiveThis study reported emergence of fluconazole resistance in C.
Mohammad Zeeshan, Saba Memon, Ayesha Malick, Syed Faheem Naqvi, Joveria Farooqi, Najia Karim Ghanchi, Kauser Jabeen   +6 more
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