Results 131 to 140 of about 2,032 (166)

Diastereoselectivity in ergoline synthesis: A face selective epoxidation

Tetrahedron Letters, 1989
Abstract Epoxidation of 1-Benzoyl-1,2,2a,3-tetrahydrobenz[ cd ]indole ( 4a ) proceeded smoothly with metachloroperbenzoic acid with high exo diastereoselectivity (de = 96%) and chemical yield (97%). The basis for this selectivity was probed with substituent effects, and was extended to other oxidation media.
Marvin Robert Leanna, Varie David Lee, Michael J. Martinelli, Kress Thomas Joseph   +3 more
openaire   +3 more sources

ChemInform Abstract: Synthesis of Chiral Indolizines as Bicyclic Ergoline Analogues.

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +3 more sources

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.

Bioorganic & Medicinal Chemistry Letters, 2011
G. Thoma, Rolf Baenteli, I. Lewis, Darryl Jones, J. Kovarik, M. Streiff, H. Zerwes   +6 more
semanticscholar   +1 more source

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Bioorganic & Medicinal Chemistry Letters, 2009
G. Thoma, Rolf Baenteli, I. Lewis, T. Wagner, L. Oberer, W. Blum, F. Glickman, M. Streiff, H. Zerwes   +8 more
semanticscholar   +1 more source

Pharmacological properties of a wide array of ergolines at functional alpha1-adrenoceptor subtypes

Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
T. Görnemann, S. Jähnichen, B. Schurad, K. Latté, R. Horowski, J. Tack, M. Flieger, H. Pertz   +7 more
semanticscholar   +1 more source

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

Molecular Pharmacology, 1994
Michael P. Johnson, R. Loncharich, Melvyn Baez, D. Nelson   +3 more
semanticscholar   +1 more source

Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines.

Journal of Pharmacology and Experimental Therapeutics, 1993
David L. Nelson, V. Lucaites, J. Audia, J. Nissen, D. B. Wainscott   +4 more
semanticscholar   +1 more source

Bromination of ergolene and ergoline structures — New results

1995
Summary The technical aspect of 2-bromo-α-ergocryptine synthesis, including the characterisation and significance of the impurities obtained in the production process, were reviewed. In the continuation new ergolene and ergoline compounds were synthesized and tested for the pharmacological activity.
openaire   +2 more sources

Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.

Journal of Pharmacology and Experimental Therapeutics, 1990
D. Coward, A. K. Dixon, S. Urwyler, T. White, A. Enz, M. Karobath, G. Shearman   +6 more
semanticscholar   +1 more source

N(1)-substituted ergolines and tryptamines show species differences for the agonist-labeled 5-HT2 receptor.

European Journal of Pharmacology, 1993
M. P. Johnson, J. Audia, J. Nissen, D. Nelson   +3 more
semanticscholar   +1 more source