Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae [PDF]
Journal of Fungi, 2021 Terpenes represent the biggest group of natural compounds on earth. This large class of organic hydrocarbons is distributed among all cellular organisms, including fungi.
Mohammad Sayari +5 more
doaj +2 more sources
Voriconazole Treatment Induces a Conserved Sterol/Pleiotropic Drug Resistance Regulatory Network, including an Alternative Ergosterol Biosynthesis Pathway, in the Clinically Important FSSC Species, Fusarium keratoplasticum [PDF]
Journal of Fungi, 2022 Fusarium keratoplasticum is the Fusarium species most commonly associated with human infections (fusariosis). Antifungal treatment of fusariosis is often hampered by limited treatment options due to resistance towards azole antifungals. The mechanisms of
Jasper E. James +3 more
doaj +2 more sources
Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis [PDF]
mSphere, 2021 Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the ...
Tomye L. Ollinger +10 more
doaj +2 more sources
Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway [PDF]
Iranian Journal of Microbiology, 2020 Over the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function.
Fatemehsadat Jamzivar +5 more
doaj +2 more sources
Enhancement and Mechanism of Ergosterol Biosynthesis in Termite Ball Fungus Athelia termitophila by Methyl Jasmonate [PDF]
Current Issues in Molecular BiologyErgosterol is a component of fungal cell membranes that has physiological functions and applications in drugs, such as anti-inflammatory, anti-tumor, anti-fungal, and other immunosuppressive activities.
Yong-Gang Fang +4 more
doaj +2 more sources
Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in Penicillium digitatum [PDF]
Journal of Fungi, 2021 Ergosterol (ERG) is a potential target for the development of antifungal agents against Penicillium digitatum, the pathogen of green mold in citrus fruits.
Qiuli OuYang +5 more
doaj +2 more sources
Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles [PDF]
Frontiers in Microbiology, 2018 Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis.
Chengcheng Hu +9 more
doaj +2 more sources
Mevalonate Diphosphate Decarboxylase MVD/Erg19 Is Required for Ergosterol Biosynthesis, Growth, Sporulation and Stress Tolerance in Aspergillus oryzae [PDF]
Frontiers in Microbiology, 2019 Mevalonate diphosphate decarboxylase (MVD; EC 4.1.1.33) is a key enzyme of the mevalonic acid (MVA) pathway. In fungi, the MVA pathway functions as upstream of ergosterol biosynthesis, and MVD is also known as Erg19.
Yunlong Sun +9 more
doaj +2 more sources
Phenotypic Analysis of Mutants of Ergosterol Biosynthesis Genes (ERG3 and ERG4) in the Red Yeast Xanthophyllomyces dendrorhous [PDF]
Frontiers in Microbiology, 2020 Xanthophyllomyces dendrorhous synthesizes astaxanthin, a carotenoid used in aquaculture. Astaxanthin is synthesized from metabolites of the mevalonate pathway, which are also precursors for sterols biosynthesis.
Maximiliano Venegas +10 more
doaj +2 more sources
Combining transcriptomics and metabolomics to reveal the underlying molecular mechanism of ergosterol biosynthesis during the fruiting process of Flammulina velutipes [PDF]
BMC Genomics, 2019 Background Flammulina velutipes has been recognized as a useful basidiomycete with nutritional and medicinal values. Ergosterol, one of the main sterols of F. velutipes is an important precursor of novel anticancer and anti-HIV drugs.
Ruihong Wang +5 more
doaj +2 more sources