Introduction to the Toxins Special Issue on Ergot Alkaloids
Ergot alkaloids are among the most relevant natural products in the history of toxins and pharmaceuticals. Until the late 20th century, human and livestock exposure to ergot alkaloids was primarily through ingestion of “ergots,” which are spur-shaped or ...
Christopher L. Schardl
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Alkaloid quantities in endophyte-infected tall fescue are affected by the plant-fungus combination and environment [PDF]
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Bush, L. P. +6 more
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The scientific research on ergot alkaloids is fundamentally related to the work of Dr. Albert Hofmann, who was able to produce, from 1935 onwards, a number of novel and valuable drugs, some of which are still in use today.
Rudolf K.A. Giger, Günter Engel
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Plant-symbiotic fungi as chemical engineers: multi-genome analysis of the Clavicipitaceae reveals dynamics of alkaloid Loci [PDF]
The fungal family Clavicipitaceae includes plant symbionts and parasites that produce several psychoactive and bioprotective alkaloids. The family includes grass symbionts in the epichloae clade (Epichloë and Neotyphodium species), which are ...
A Dereeper +171 more
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Arterial Responses to Acute Low-Level Ergot Exposure in Hereford Cows
Ergot alkaloids are toxic secondary metabolites produced by the fungus Claviceps purpurea that contaminate cereal grains. Current Canadian standards allow 2 to 3 parts per million of ergot alkaloids in animal feed.
Vanessa Elizabeth Cowan +7 more
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BMC Microbiology / Rhodococcus erythropolis MTHt3 biotransforms ergopeptines to lysergic acid [PDF]
Background: Ergopeptines are a predominant class of ergot alkaloids produced by tall fescue grass endophyte Neotyphodium coenophialum or cereal pathogen Claviceps purpurea.
Apfelthaler, Elisabeth +7 more
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Genetics, Genomics and Evolution of Ergot Alkaloid Diversity
The ergot alkaloid biosynthesis system has become an excellent model to study evolutionary diversification of specialized (secondary) metabolites. This is a very diverse class of alkaloids with various neurotropic activities, produced by fungi in several
Carolyn A. Young +8 more
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Fungi - an Amalgam of Toxins and Antibiotics: a Mini- Review [PDF]
Fungi are eukaryotes with many functions. Earlier, fungi were classified in the plant kingdom but were later classified as a separate kingdom due to their unique cell walls. Fungi are heterotrophs like animals and are more closely related to animals. The
Ahmed, M. (Muddassir) +3 more
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Relationships among Ergot Alkaloids, Cytochrome P450 Activity, and Beef Steer Growth
Determining a grazing animal’s susceptibility to ergot alkaloids has been a research topic for decades. Our objective was to determine if the Promega™ P450-Glo assay could be used to indirectly detect ergot alkaloids or their metabolites in urine of ...
Charles F. Rosenkrans, Nicholas S. Ezell
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Mycotoxin occurrence in maize silage : a neglected risk for bovine gut health? [PDF]
Forages are important components of dairy cattle rations but might harbor a plethora of mycotoxins. Ruminants are considered to be less susceptible to the adverse health effects of mycotoxins, mainly because the ruminal microflora degrades certain ...
Antonissen, Gunther +6 more
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