Results 91 to 100 of about 511,445 (325)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Business Startups: Cultural-Economic Controversy [PDF]

The purpose of this paper is to examine whether national cultural differences and/or economic, macroeconomic indicators are dominant in explaining business startups in selected EU countries.
Nejat Erk, Sinan Fikret Erk
core  

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

Pharmaceutical Biology, 2020
Context Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.
Wen-qiang Cao, Xiao-qian Zhai, Ji-wei Ma, Xue-qi Fu, Bai-song Zhao, Pu Zhang, Xiao-yan Fu   +6 more
doaj   +1 more source

Inhibition of ERK Dimerization Impairs RAS–ERK-Driven Tumorigenesis [PDF]

Cancer Discovery, 2015
Abstract Small-molecule blockade of ERK dimerization delays tumorigenesis driven by oncogenic RAS–ERK signaling.
openaire   +1 more source

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina, Chu, Jennifer, Pelletier, Jerry, Porco, John A., Wang, Wenyu   +4 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic Fibrogenesis

Cells, 2019
The activation of hepatic stellate cells (HSCs) manifested as proliferation and migration is the pivotal event involved in liver fibrogenesis. The vimentin network, an intermediate filament (IF) system, is one of the critical cascades by which the cell ...
Pei-Wen Wang, Tung-Ho Wu, Tung-Yi Lin, Mu-Hong Chen, Chau-Ting Yeh, Tai-Long Pan   +5 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source