Results 1 to 10 of about 33,348 (245)

Structure of cellular ESCRT-III spirals and their relationship to HIV budding [PDF]

eLife, 2014
The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Anil G Cashikar, Soomin Shim, Robyn Roth, Michael R Maldazys, John E Heuser, Phyllis I Hanson   +5 more
doaj   +6 more sources

The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes

The EMBO Journal
The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of ...
Nataly Melnikov, Benedikt Junglas, Gal Halbi, Dikla Nachmias, Erez Zerbib, Noam Gueta, Alexander Upcher, Ran Zalk, Carsten Sachse, Anne Bernheim-Groswasser, Natalie Elia   +10 more
doaj   +3 more sources

Insights into the function of ESCRT and its role in enveloped virus infection

Frontiers in Microbiology, 2023
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang, Yu Chen, Shunlin Hu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +5 more
doaj   +2 more sources

Diversity, origin, and evolution of the ESCRT systems

mBio
Endosomal sorting complexes required for transport (ESCRT) play key roles in protein sorting between membrane-bounded compartments of eukaryotic cells.
Kira S. Makarova, Victor Tobiasson, Yuri I. Wolf, Zhongyi Lu, Yang Liu, Siyu Zhang, Mart Krupovic, Meng Li, Eugene V. Koonin   +8 more
doaj   +2 more sources

A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon

mBio
Cell division is a fundamental process ensuring the perpetuation of all cellular life forms. Archaea of the order Sulfolobales divide using a simpler version of the eukaryotic endosomal sorting complexes required for transport (ESCRT) machinery, composed
Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic   +6 more
doaj   +2 more sources

ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases

Animal Cells and Systems
The endosomal sorting complexes required for transport (ESCRT) machinery is an evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane remodeling and scission events across eukaryotes.
Jisoo Park, Jongyoon Kim, Hyungsun Park, Taewan Kim, Seongju Lee   +4 more
doaj   +2 more sources

The Dynamics of the ESCRT Machinery in Open Mitosis from Physiology to Pathology [PDF]

Cells
The Endosomal Sorting Complex Required for Transport (ESCRT) is a highly conserved machinery best known for its role in endosomal trafficking and membrane remodeling.
Mattia La Torre, Federica Cannistrà, Romina Burla, Isabella Saggio   +3 more
doaj   +2 more sources

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Membranes, 2022
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
doaj   +2 more sources

Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease

Nucleus
The ESCRT machinery plays a pivotal role in membrane-remodeling events across multiple cellular processes including nuclear envelope repair and reformation, nuclear pore complex surveillance, endolysosomal trafficking, and neuronal pruning.
Olivia Keeley, Alyssa N. Coyne
doaj   +2 more sources

Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery

Cells
The endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of the
Mattia La Torre, Romina Burla, Isabella Saggio   +2 more
doaj   +2 more sources