Results 91 to 100 of about 33,348 (245)

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

, 2019
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya, Dimitrios Papagiannidis, Giulia Ruffini, Jasmin A Schäfer, Julia P Schessner, Katharina Schaeff, Michael Knop, Oliver Pajonk, Peter W Bircham, Sebastian Schuck, Takuma Tsuji, Toyoshi Fujimoto, Vergères G   +12 more
core   +2 more sources

Correction to: ESCRT-III-Associated Protein ALIX Mediates High-Affinity Phosphate Transporter Trafficking to Maintain Phosphate Homeostasis in Arabidopsis [PDF]

, 2022
Ximena Cardona-López, Laura Cuyas, Elena Marín, Charukesi Rajulu, María Luisa Irigoyen, Erica Gil, María Isabel Puga, Richard Bligny, Laurent Nussaume, Niko Geldner, Javier Paz‐Ares, Vicente Rubio   +11 more
openalex   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Complex polarity: building multicellular tissues through apical membrane traffic [PDF]

, 2016
The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization.
Adams, Allaire, Altschuler, Ang, Aranda, Assemat, Bai, Baker, Balda, Balklava, Bedzhov, Benton, Betschinger, Blankenship, Boehlke, Bryant, Bryant, Bryant, Bulgakova, Butty, Campbell, Cancino, Chen, Chiba, Colley, Denef, Devenport, Dhekne, Eaton, Elias, Feldman, Ferrari, Fletcher, Galvez-Santisteban, Gamblin, Gangar, Gao, Gao, Gassama-Diagne, Georgiou, Gillard, Goldstein, Grawe, Graybill, Hammer, Hao, Hariharan, Harris, Harris, Harris, Hehnly, Hehnly, Hung, Hurd, Hurov, Hutterer, Hyenne, Izumi, Izumi, Joberty, Johnson, Kemphues, Klebes, Klinkert, Klose, Krahn, Kroschewski, Kumar, Kumichel, Kusakabe, Langevin, Leibfried, Lerner, Li, Li, Li, Lin, Lin, Ling, Liu, Lock, Lu, Macara, Martin-Belmonte, McGill, Melendez, Menut, Michaux, Moberg, Morais-de-Sa, Morrison, Mrozowska, Muller, Musch, Nakayama, Nakayama, Nakayama, Neisch, Ozdamar, Parsons, Pellikka, Pinal, Plant, Pocha, Pocha, Richards, Robinson, Rodriguez-Boulan, Rodriguez-Fraticelli, Rodriguez-Fraticelli, Roeth, Roland, Rossi, Sahlender, Sakamori, Sato, Satoh, Schluter, Schottenfeld-Roames, Shafaq-Zadah, Sherrard, Shewan, Shivas, Sobajima, Sollier, Stepensky, Suzuki, Takahama, Taniguchi, Tepass, Tepass, Tepass, Thuenauer, Toro, Vaccari, Vaccari, Varelas, Vermeer, Vogel, Vogel, Vreede, Wang, Wang, Wang, Wedlich-Soldner, Wei, Wiegerinck, Willenborg, Winter, Xiong, Xiong, Yamanaka, Yamanaka, Zhang, Zhang, Zhou, Zihni, Zou   +157 more
core   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Three-dimensional architecture of ESCRT-III flat spirals on the membrane

Proceedings of the National Academy of Sciences of the United States of America
Significance The endosomal sorting complexes required for transport (ESCRTs) play a vital role in many cellular processes by helping to reshape membranes, and dysfunction of ESCRTs is associated with many human diseases, such as cancer and ...
Mingdong Liu, Yunhui Liu, Tiefeng Song, Liuyan Yang, Lei Qi, Yuzhong Zhang, Yong Wang, Qing-Tao Shen   +7 more
semanticscholar   +1 more source

A cell-based assay for CD63-containing extracellular vesicles [PDF]

, 2019
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core   +2 more sources

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source