Results 111 to 120 of about 33,348 (245)

Super-resolution imaging of ESCRT-proteins at HIV-1 assembly sites.

PLoS Pathogens, 2015
The cellular endosomal sorting complex required for transport (ESCRT) machinery is involved in membrane budding processes, such as multivesicular biogenesis and cytokinesis.
Jens Prescher, Viola Baumgärtel, Sergey Ivanchenko, Adriano A Torrano, Christoph Bräuchle, Barbara Müller, Don C Lamb   +6 more
doaj   +1 more source

CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines.: CHMP2B and dendritic spines [PDF]

, 2010
International audienceThe highly conserved ESCRT-III complex is responsible for deformation and cleavage of membranes during endosomal trafficking and other cellular activities.
Bajorek, Banker, Boyer, Carlton, Fabrikant, Ferrer, Fiala, Filimonenko, Hamill, Hanson, Henkemeyer, Hurley, Lata, Lee, Lee, Lipton, Matsuzaki, Morfini, Muziol, Noguchi, Passafaro, Rodriguez, Rodriguez, Rusten, Saksena, Sevrioukov, Skibinski, Slagsvold, Stuchell-Brereton, Sweeney, Urwin, Vaccari, von Schwedler, Wei, Wishart, Wollert, Wollert, Yasumatsu, Zamborlini   +38 more
core   +3 more sources

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. [PDF]

, 2016
Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ...
Benovic, Jeffrey L., Bowman, Shanna L., Du, Yang, Irannejad, Roshanak, Puthenveedu, Manojkumar A., Tian, Xufan, von Zastrow, Mark   +6 more
core   +2 more sources

Proteomic and Lipidomic Profiling of Immune Cell‐Derived Subpopulations of Extracellular Vesicles

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Anna Lischnig, Nasibeh Karimi, Per Larsson, Karin Ekström, Rossella Crescitelli, Anna‐Carin Olin, Cecilia Lässer   +6 more
wiley   +1 more source

Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation [PDF]

, 2010
endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs).
Auciello, Giulio, Dafforn, Tim R., Heath, John K, Mardakheh, Faraz K., Rappoport, Joshua Z.   +4 more
core   +2 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment

mBio, 2016
Enveloped viruses commonly utilize late-domain motifs, sometimes cooperatively with ubiquitin, to hijack the endosomal sorting complex required for transport (ESCRT) machinery for budding at the plasma membrane. However, the mechanisms underlying budding
Rina Barouch-Bentov, Gregory Neveu, Fei Xiao, Melanie Beer, Elena Bekerman, Stanford Schor, Joseph Campbell, Jim Boonyaratanakornkit, Brett Lindenbach, Albert Lu, Yves Jacob, Shirit Einav   +11 more
doaj   +1 more source

Multifaceted interactions between host ESCRT-III and budded virus-related proteins involved in entry and egress of the baculovirus Autographa californica multiple nucleopolyhedrovirus

Journal of Virology
The endosomal sorting complex required for transport (ESCRT) is a conserved protein machine mediating membrane remodeling and scission. In the context of viral infection, different components of the ESCRT-III complex, which serve as the core machinery to
Lisha Bai, Yu Sun, Xiaorong Yue, Ning Ji, Fanye Yan, Tian Yang, Guozhong Feng, Ya Guo, Zhaofei Li   +8 more
semanticscholar   +1 more source

ESCRT function in cytokinesis : location, dynamics and regulation by mitotic kinases [PDF]

, 2014
Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring
Bhutta, Musab S., Gould, Gwyn W., McInerny, Christopher J.   +2 more
core   +1 more source