Results 121 to 130 of about 33,348 (245)

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis

Nature Communications, 2018
Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation.
Jinbo Shen, Qiong Zhao, Xiangfeng Wang, Caiji Gao, Ying Zhu, Yonglun Zeng, Liwen Jiang   +6 more
doaj   +1 more source

ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.

PLoS ONE, 2014
Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon, Nadine Wollscheid, Katia Cortese, Carlo Tacchetti, Thomas Vaccari   +4 more
doaj   +1 more source

AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway [PDF]

, 2012
The sorting of signaling receptors within the endocytic system is important for appropriate cellular responses. After activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosomes and degraded.
Dores, Michael R, Lin, Huilan, Marchese, Adriano, Montagne, William A, Paing, May M, Trejo, JoAnn   +5 more
core   +2 more sources

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen, Mingjie Wu, Xiao Guo, Hongmei Xu, Chenwei Feng, Duxuan Liu, Jing Hua, Yanhong Hua, Zhen He, Peter Moffett, Kun Zhang   +10 more
wiley   +1 more source

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Science, 2018
Fine-tuning pyroptosis with ESCRT-III Pyroptosis is an inflammatory form of cell death induced by select caspases downstream of inflammasome complexes. These caspases cleave gasdermin D (GSDMD), whose N-terminal fragments quickly form large permeability ...
S. Rühl, K. Shkarina, B. Demarco, Rosalie Heilig, J. C. Santos, P. Brož   +5 more
semanticscholar   +1 more source

Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding

, 2017
During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of a nucleocapsid core is not required for assembly of infectious particles.
Hagan, Michael F., Lazaro, Guillermo R., Mukhopadhyay, Suchetana   +2 more
core   +1 more source

The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application [PDF]

, 2019
Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of valid biomarker that accurately predict the risk of developing cardiovascular disease, and novel therapeutic approaches for its ...
Avan, Amir, Ferns, Gordon A, Ghafarian, Farzaneh, Hassanian, Seyed Mahdi, Khazaei, Majid, Pashirzad, Mehran, Rezayi, Majid   +6 more
core   +1 more source

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

A non-canonical ESCRT pathway, including His domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC Class I [PDF]

, 2015
The Kaposi’s sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC Class I. K3 is an E3 ubiquitin ligase that promotes K63-linked polyubiquitination of MHC Class I, providing the signal for clathrin ...
Boname, JM, Bowers, K, Bright, NA, Evans, JL, Lehner, PJ, Luzio, JP, Parkinson, MDJ, Piper, SC   +7 more
core