Results 11 to 20 of about 33,348 (245)
ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes
Journal of Cell Biology, 2020 ALIX recruits ESCRT-III onto endosomes in a process that does not depend on other ESCRTs but requires the late endosome–specific lipid LBPA in vivo and in vitro. This novel pathway of ILV formation promotes tetraspanin sorting and delivery to exosomes.
Jorge A Larios +3 more
semanticscholar +2 more sources
Autophagy Reports, 2023 Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death.
Ron Benyair +16 more
doaj +2 more sources
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery [PDF]
Nature Communications, 2022 The ESCRT machinery, comprising of multiple proteins and subcomplexes, is crucial for membrane remodelling in eukaryotic cells, in processes that include ubiquitin-mediated multivesicular body formation, membrane repair, cytokinetic abscission, and virus
T. Hatano +18 more
semanticscholar +2 more sources
Autophagy, 2023 Dysfunction of the endosomal sorting complex required for transport (ESCRT) has been linked to frontotemporal dementia (FTD) due in part to the accumulation of unsealed autophagosomes.
Yong‐Woo Jun +4 more
semanticscholar +2 more sources
RAB31 marks and controls an ESCRT-independent exosome pathway [PDF]
Cell Research, 2020 Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored.
D. Wei +9 more
semanticscholar +2 more sources
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis. [PDF]
Developmental Cell, 2023 Yu Jin Lee +14 more
semanticscholar +2 more sources
ATG and ESCRT control multiple modes of microautophagy [PDF]
FEBS Letters, 2023 The discovery of microautophagy, the direct engulfment of cytoplasmic material by the lysosome, dates back to 1966 in a morphological study of mammalian cells by Christian de Duve. Since then, studies on microautophagy have shifted toward the elucidation
Y. Sakai, Masahide Oku
semanticscholar +2 more sources
Nature Cell Biology, 2023 Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the endoplasmic reticulum to the Golgi where STING activates the ...
Yoshihiko Kuchitsu +23 more
semanticscholar +1 more source
A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe [PDF]
, 2014 Cytokinesis and cell separation are critical events in the cell cycle. We show that Endosomal Sorting Complex Required for Transport (ESCRT) genes are required for cell separation in Schizosaccharomyces pombe.
Bhutta, Musab S. +3 more
core +14 more sources
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang +5 more
doaj +1 more source