Results 21 to 30 of about 33,348 (245)

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Nature Communications, 2023
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses ...
M. Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O. Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steve Carr, N. Hacohen   +11 more
semanticscholar   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +13 more sources

Design principles of the ESCRT-III Vps24-Vps2 module

eLife, 2021
ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process.
Sudeep Banjade, Yousuf H Shah, Shaogeng Tang, Scott D Emr   +3 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

The Endosomal Sorting Complex, ESCRT, has diverse roles in blood progenitor maintenance, lineage choice and immune response [PDF]

Biology Open
Arindam Ray, Yashashwinee Rai, Maneesha S. Inamdar   +2 more
doaj   +2 more sources

Involvement of ESCRT-II in hepatitis B virus morphogenesis. [PDF]

PLoS ONE, 2014
The hepatitis B virus (HBV) is an enveloped DNA virus that replicates via reverse transcription of its pregenomic RNA (pgRNA). Budding of HBV is supposed to occur at intracellular membranes and requires scission functions of the endosomal sorting complex
Jens T Stieler, Reinhild Prange
doaj   +1 more source

Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]

, 2018
Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I, Köster, Stefan, Mehra, Alka, Mittal, Ekansh, Philips, Jennifer A, Skowyra, Michael L, Tinaztepe, Emir, Uwase, Grace   +7 more
core   +2 more sources

Termination of STING responses is mediated via ESCRT‐dependent degradation

EMBO Journal, 2023
cGAS‐STING signalling is induced by detection of foreign or mislocalised host double‐stranded (ds)DNA within the cytosol. STING acts as the major signalling hub, where it controls production of type I interferons and inflammatory cytokines.
Katherine R Balka, Rajan Venkatraman, Tahnee L. Saunders, Angus Shoppee, E. S. Pang, Zoe Magill, Jihane Homman-Ludiye, Cheng Huang, Rachael M. Lane, H. York, Peck Tan, R. Schittenhelm, S. Arumugam, B. Kile, M. O’Keeffe, D. De Nardo   +15 more
semanticscholar   +1 more source

ESCRT-III mediated cell division in Sulfolobus acidocaldarius - a reconstitution perspective [PDF]

, 2014
In the framework of synthetic biology, it has become an intriguing question what would be the minimal representation of cell division machinery. Thus, it seems appropriate to compare how cell division is realized in different microorganisms. Inparticular,
Härtel, T., Schwille, P.
core   +2 more sources

Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum

Frontiers in Microbiology, 2019
Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction.
Qiurong Xie, Qiurong Xie, Ahai Chen, Ahai Chen, Yunzhi Zhang, Yunzhi Zhang, Mingyue Yuan, Mingyue Yuan, Wei Xie, Wei Xie, Chengkang Zhang, Chengkang Zhang, Wenhui Zheng, Wenhui Zheng, Zonghua Wang, Zonghua Wang, Guangpu Li, Guangpu Li, Jie Zhou, Jie Zhou   +19 more
doaj   +1 more source