Results 81 to 90 of about 33,348 (245)
Advanced Science, EarlyView.This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir +7 more
wiley +1 more source
Interplay of the nuclear envelope with chromatin in physiology and pathology
Nucleus, 2020 The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins.
Romina Burla +5 more
doaj +1 more source
BMC Biology, 2021 Background Comparing a parasitic lineage to its free-living relatives is a powerful way to understand how that evolutionary transition to parasitism occurred.
Shweta V. Pipaliya +8 more
doaj +1 more source
A role for Vps13-mediated lipid transfer at the ER–endosome contact site in ESCRT-mediated sorting
Journal of Cell BiologySuzuki et al. reveal a critical role for Vps13-mediated lipid transfer at ER–endosome contact sites in ESCRT-mediated sorting, elucidating the contribution of the ER to membrane protein sorting at endosomes.
Sho W. Suzuki +6 more
semanticscholar +1 more source
CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]
, 2017 Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie +1 more
core +1 more source
Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
core +2 more sources
Advanced Science, EarlyView.To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun +6 more
wiley +1 more source
Annexin A7 mediates lysosome repair independently of ESCRT-III
Frontiers in Cell and Developmental BiologyLysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 ...
M. L. Ebstrup +8 more
semanticscholar +1 more source
Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair
Nature Communications, 2021 Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability.
Patrick Niekamp +12 more
semanticscholar +1 more source
Role of metal-dependent regulation of ESX-3 secretion in intracellular survival of Mycobacterium tuberculosis [PDF]
, 2016 More people die every year from Mycobacterium tuberculosis infection than from infection by any other bacterial pathogen. Type VII secretion systems (T7SS) are used by both environmental and pathogenic mycobacteria to secrete proteins across their ...
Philips, Jennifer A +5 more
core +2 more sources